ArticleNature2024
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
23.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 53 citations in OpenAlex.
- Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered NaMolecular psychiatry · 2026Article
- Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.FEBS open bio · 2026Article
- Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia.European journal of neurology · 2026Article
- The Target ALS Global Natural History Study: Cross-platform proteomics to accelerate biofluid biomarker and drug target discovery in amyotrophic lateral sclerosis.medRxiv : the preprint server for health sciences · 2026Article
- Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE).Acta neuropathologica · 2026Review
- Article
- Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.Nature communications · 2026Article
- A semi-automated MEA spike sorting method for high-throughput assessment of cultured neurons.Stem cell reports · 2026Article
- Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identifying GFAP-expressing cell susceptibility to SARS-CoV-2 infection using human iPSC-derived neural cells.Scientific reports · 2026Article
- Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2.Scientific reports · 2026Article
- CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals.Annals of clinical and translational neurology · 2026Article
- Reply to "Extending the Interpretation of Biomarker Dynamics in SOD1-ALS Proteomics".Annals of neurology · 2026Article
- Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain.bioRxiv : the preprint server for biology · 2026Article
- Value of synaptic proteins as biomarkers in amyotrophic lateral sclerosis.Brain communications · 2026Article
- Beyond motor neurons: peripheral TDP-43 pathology in skeletal muscle and intramuscular nerves in amyotrophic lateral sclerosis.Brain communications · 2026Review
- Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes.bioRxiv : the preprint server for biology · 2025Article
- Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1-Linked Amyotrophic Lateral Sclerosis.Annals of neurology · 2025Article
- Serum neuronal pentraxin 2 levels are associated with shorter survival in amyotrophic lateral sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Induced Pluripotent Stem Cells for the Treatment of Lysosomal Storage Disorders.Journal of inherited metabolic disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 3 countries.
Marian Hruska-PlochanDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9253-4362
Vera I Wiersma *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8223-4588
Katharina M Betz *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5041-6205
Izaskun Mallona *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-2853-7526
Silvia Ronchi *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Zuzanna ManieckaDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Eva-Maria HockDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Elena TantardiniDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9189-3390
Florent LaferriereDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0753-5505
Sonu SahadevanDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Vanessa HoopDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Igor DelvendahlDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-6151-2363
Manuela Pérez-BerlangaDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9064-9724
Beatrice GattaDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Martina PanattaDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Alexander van der BourgBrain Research Institute, University of Zurich, Zurich, Switzerland.
Dasa BohaciakovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.ORCID 0000-0002-9538-6668
Puneet SharmaDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.ORCID 0000-0003-0566-9005
Laura De VosDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6675-6968
Karl FrontzekInstitute of Neuropathology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0945-8857
Adriano AguzziInstitute of Neuropathology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0344-6708
Tammaryn LashleyQueen Square Brain Bank for Neurological diseases, Department of Movement Disorders, UCL Institute of Neurology, London, UK.ORCID 0000-0001-7389-0348
Mark D RobinsonDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Theofanis KarayannisBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-3267-6254
Martin MuellerDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-1624-6761
Andreas HierlemannDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0000-0002-3838-2468
Magdalini PolymenidouDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. magdalini.polymenidou@uzh.ch.ORCID 0000-0003-1271-9445
University of Zurich · CHSIB Swiss Institute of Bioinformatics · CHETH Zurich · CHMasaryk University · CZNational Hospital for Neurology and Neurosurgery · GBUniversity of Bern · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies
Indexed as
Amyotrophic Lateral SclerosisC-Reactive ProteinDNA-Binding ProteinsFrontotemporal Lobar DegenerationNerve NetNerve Tissue ProteinsNeuronsHumansNeural Stem CellsNeurogliaPentraxinsReproducibility of ResultsC-Reactive ProteinDNA-Binding ProteinsNerve Tissue ProteinsPentraxinsTARDBP protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.