Evidence map›Paper›PMID 38355791›Full record

Trial reportNature2024

Smoking changes adaptive immunity with persistent effects.

Violaine Saint-André, Bruno Charbit, Anne Biton, Vincent Rouilly, Céline Possémé, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L Albert and 3 more

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 3 pooled it
37.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 3 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Pooled it
  2. Differential Efficacy of Advanced Therapies in Inducing Remission in Ulcerative Colitis Based on Prior Exposure to TNF Antagonists.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Interaction between smoking andMultiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Cigarette smoking exposure and clinical outcomes in Graves' disease.The Journal of clinical endocrinology and metabolism · 2026
    Observational
  14. Article
  15. CIITA/PRMT5 promote CD4BMC medicine · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Violaine Saint-AndréTranslational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France. violaine.saint-andre@pasteur.fr.ORCID 0000-0002-2162-0909
Bruno CharbitCytometry and Biomarkers UTechS, Center for Translational Research, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-5478-482X
Anne BitonInstitut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.
Vincent RouillyDATACTIX, Paris, France.
Céline PosséméTranslational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France.
Anthony BertrandTranslational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France.
Maxime RotivalInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.ORCID 0000-0003-2519-8044
Jacob BergstedtInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.
Etienne PatinInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.ORCID 0000-0002-9911-4459
Matthew L AlbertOctant Biosciences, San Francisco, CA, USA.ORCID 0000-0001-7285-6973
Lluis Quintana-MurciInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.ORCID 0000-0003-2429-6320
Darragh DuffyTranslational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France. darragh.duffy@pasteur.fr.ORCID 0000-0002-8875-2308
Milieu Intérieur Consortium
Institut Pasteur · FRInserm · FRCentre National de la Recherche Scientifique · FRTrinity College Dublin · IEConservatoire National des Arts et Métiers · FRKarolinska Institutet · SEÉcole Polytechnique Fédérale de Lausanne · CHHôpital Necker-Enfants Malades · FRRoche (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability

Indexed as

Adaptive ImmunitySmokingAntigens, CDAutoimmune DiseasesBody Mass IndexCell Adhesion MoleculesCytokinesCytomegalovirusDNA MethylationEpigenesis, GeneticFemaleGPI-Linked ProteinsHumansImmunity, InnateInfectionsMaleAntigens, CDCEACAM6 protein, humanCell Adhesion MoleculesCytokinesGPI-Linked Proteins

Identifiers

PMID38355791
PMCPMC10881394
OpenAlexW4391824031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.