ArticleMolecular psychiatry2024
Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.
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Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Genetic variation in BDNF is associated with opioid use disorder severity.Human genetics · 2026Article
- Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.Research square · 2026Article
- Article
- Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.BMC medicine · 2026Article
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits.medRxiv : the preprint server for health sciences · 2025Article
- Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Nature human behaviour · 2025Article
- Gene discovery and pleiotropic architecture of chronic pain in a genome-wide association study of >1.2 million individuals.Research square · 2025Article
- Gene discovery and pleiotropic architecture of Chronic Pain in a Genome-wide Association Study of >1.2 million Individuals.medRxiv : the preprint server for health sciences · 2025Article
- Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors.Translational psychiatry · 2025Article
- Chronic Pain and Substance Use Disorders: A Brief Narrative Review of Genetic, Neurobiological, and Environmental Contributions to Comorbidity.Journal of psychiatry and brain science · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Dora KollerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. dora.koller@yale.edu.ORCID 0000-0002-0415-0466
Eleni FriligkouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0003-3682-0991
Brendan StiltnerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Gita A PathakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Solveig LøkhammerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8431-9569
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7694-6391
Alexander S HatoumDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0000-0002-8002-7267
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0540-6080
Rachel L KemberDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-8820-2659
Jorien L TreurDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9564-2871
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4067-1859
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. renato.polimanti@yale.edu.ORCID 0000-0003-0745-6046
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MRESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MLeveraging genomic data to dissect the association of internalizing disorders with the risk, onset, and vulnerability of COVID-19RF1MH132337 · NIMH · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2022 to 2022
$3.7MInvestigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0MTranslational Alcohol Research Program (TARP)T32AA028259 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P., VASILIOU, VASILIS · 2020 to 2024
$1.8MIdentifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816kMulti-modal intersection of depression and genetic liability to Alzheimers diseaseR00AG078503 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Gita A Pathak · 2024 to 2026
$741kGenome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking BehaviorsR21DC018098 · NIDCD · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2021
$440kMulti-modal intersection of depression and genetic liability to Alzheimers diseaseK99AG078503 · NIA · YALE UNIVERSITY · PI PATHAK, GITA A · 2022 to 2023
$203kAlzheimer's Association AARF-22-967171EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 101028810NCATS NIH HHS UL1 TR001863NIAAA NIH HHS T32 AA028259NIA NIH HHS K99 AG078503NIA NIH HHS R00 AG078503NIDA NIH HHS K01 DA051759NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS RF1 MH132337NIMH NIH HHS T32 MH014276U.S. Department of Health & Human Services | National Institutes of Health (NIH) R33 DA047527, R21 DC018098, RF1 MH132337
Abstract
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, N
Indexed as
Chronic PainGenetic PleiotropyGenome-Wide Association StudyPolymorphism, Single NucleotideSubstance-Related DisordersAdultAlcoholismComorbidityFemaleGenetic Predisposition to DiseaseHumansMaleMarijuana AbuseMendelian Randomization AnalysisMiddle AgedOpioid-Related Disorders
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