ArticleScientific reports2024
A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Computational study of DurystaDrug delivery and translational research · 2026Article
- Creating Blood Analogs to Mimic Steady-State Non-Newtonian Shear-Thinning Characteristics Under Various Thermal Conditions.Bioengineering (Basel, Switzerland) · 2025Article
- Minimally Invasive Glaucoma Surgery Procedure in the Human Eye. A Fluid Structure Interaction Study.International journal for numerical methods in biomedical engineering · 2025Article
- Shannon Entropy in Uncertainty Quantification for the Physical Effective Parameter Computations of Some Nanofluids.Nanomaterials (Basel, Switzerland) · 2025Article
- [EndoArt®: results in patients with glaucoma drainage devices].Die Ophthalmologie · 2024Article
- Rheological Behavior of an Aqueous Suspension of Oxidized Carbon Nanohorn (CNHox).Nanomaterials (Basel, Switzerland) · 2024Article
- Advancing Thrombosis Research: A Novel Device for Measuring Clot Permeability.Sensors (Basel, Switzerland) · 2024Article
- Short-Term Outcomes of PreserFlo for Secondary Glaucoma after Combined Descemet Stripping Automated Endothelial Keratoplasty and Artificial Iris-Intraocular Lens Implantation: A Case Report.Case reports in ophthalmologyArticle
- Likelihood of Corneal Transplantation after Tube versus Trabeculectomy: An IRIS® Registry Study.Ophthalmology. GlaucomaArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall. A computational fluid dynamics (CFD) model was used to investigate this hypothesis in silico. The Ahmed Glaucoma Valve (AGV) was selected as the subject of this study using an idealised 3D model of the anterior chamber with insertion angles and positions that are commonly used in clinical practice. It was found that a tube-cornea distance of 1.27 mm or greater does not result in a wall shear stress (WSS) above the limit where ECD could occur. Similarly, a tube-cornea angle of 45° or more was shown to be preferable. It was also found that the ECD region has an irregular shape, and the aqueous humour flow fluctuates at certain insertion angles and positions. This study shows that pathological amounts of WSS may occur as a result of certain GDD placements. Hence, it is imperative to consider the associated fluid force interactions when performing the GDD insertion procedure.
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