Evidence map›Paper›PMID 38355654›Full record

ArticleBorderline personality disorder and emotion dysregulation2024

The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.

Oladapo Babajide, Alisa D Kjaergaard, Weichen Deng, Aleksander Kuś, Rosalie B T M Sterenborg, Bjørn Olav Åsvold, Stephen Burgess, Alexander Teumer, Marco Medici, German Borderline Genomics Consortium and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 7 countries.

Oladapo BabajideQueen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Alisa D KjaergaardAarhus University Hospital, Steno Diabetes Center, Hedeager Aarhus, Denmark.
Weichen DengQueen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Aleksander KuśDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Rosalie B T M SterenborgErasmus Medical Center, Academic Center for Thyroid Diseases, Department of Internal Medicine, Rotterdam, Netherlands.
Bjørn Olav ÅsvoldDepartment of Public Health and Nursing, Department of Endocrinology, Clinic of Medicine, NTNU, Norwegian University of Science and Technology &, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Stephen BurgessUniversity of Cambridge, MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
Alexander TeumerInstitute of Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Marco MediciErasmus Medical Center, Academic Center for Thyroid Diseases, Department of Internal Medicine, Rotterdam, Netherlands.
German Borderline Genomics Consortium
Christina EllervikDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.
Bass NickDivision of Psychiatry, University College London, Mental Health Neuroscience, London, UK.
Panos DeloukasQueen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
Eirini MarouliQueen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK. e.marouli@qmul.ac.uk.
Queen Mary University of London · GBBoston Children's Hospital · USErasmus MC · NLMedical University of Warsaw · PLNorwegian University of Science and Technology · NORadboud University Nijmegen · NLSteno Diabetes Centers · DKUniversitätsmedizin Greifswald · DEUniversity College London · GBUniversity of Cambridge · GBWilliam Harvey Research Institute · GB

Funding

Wellcome Trust 100114
6 · The paper itself

Abstract

backgroundGenome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ.

methodsWe employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association.

resultsGenetically predicted higher FT4 was not associated with the risk of BPD (OR: 1.18; P = 0.60, IVW) or the risk of SCZ (OR: 0.93; P = 0.19, IVW). Genetically predicted higher TSH was not associated with the risk of BPD (OR: 1.11; P = 0.51, IVW) or SCZ (OR: 0.98, P = 0.55, IVW). Genetically predicted hypothyroidism was not associated with BPD or SCZ. We found no evidence for a reverse causal effect between BPD or SCZ on thyroid function.

conclusionsWe report evidence for a null association between genetically predicted FT4, TSH or hypothyroidism with BPD or SCZ risk. There was no evidence for reverse causality.

Indexed as

Borderline Personality DisorderFT4Mendelian RandomisationSchizophreniaThyroid functionTSH

Identifiers

PMID38355654
PMCPMC10868101
OpenAlexW4392783688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.