Evidence map›Paper›PMID 38355648›Full record

ArticleItalian journal of pediatrics2024

Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study.

Valeria Calcaterra, Veronica Maria Tagi, Enza D'Auria, Alessia Lai, Sara Zanelli, Chiara Montanari, Elia Maria Biganzoli, Giuseppe Marano, Elisa Borghi, Valentina Massa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Observational
  4. Symptoms of long COVID in children and adolescents: a scoping review.Revista da Escola de Enfermagem da U S P · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Valeria CalcaterraDepartment of Internal Medicine and Therapeutics, University of Pavia, Via Aselli 2, 27100, Pavia, Italy. valeria.calcaterra@unipv.it.ORCID http://orcid.org/0000-0002-2137-5974
Veronica Maria TagiPediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy.
Enza D'AuriaPediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy.
Alessia LaiDepartment of Biomedical and Clinical Sciences, University of Milan, 20157, Milan, Italy.
Sara ZanelliPediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy.
Chiara MontanariPediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy.
Elia Maria BiganzoliDepartment of Biomedical and Clinical Sciences, University of Milan, 20157, Milan, Italy.
Giuseppe MaranoDepartment of Biomedical and Clinical Sciences, University of Milan, 20157, Milan, Italy.
Elisa BorghiDepartment of Health Sciences, University of Milan, 20142, Milan, Italy.
Valentina MassaDepartment of Health Sciences, University of Milan, 20142, Milan, Italy.
Agostino RivaDepartment of Biomedical and Clinical Sciences, University of Milan, 20157, Milan, Italy.
Gianvincenzo ZuccottiPediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy.
University of Milan · ITOspedale dei Bambini Vittore Buzzi · ITUniversity of Pavia · IT

Funding

Horizon 2020 COVICIS project number 101046041
6 · The paper itself

Abstract

backgroundLimited evidence exists regarding the association between COVID-19 and Long COVID manifestations in children, particularly concerning variants of concern (VOCs). We aimed to characterize a cohort of pediatric patients hospitalized with confirmed acute SARS-CoV-2 and monitor them for Long COVID symptoms. Additionally, it seeks to explore any potential correlations between VOCs and clinical symptoms.

methodsWe conducted a prospective study involving children hospitalized from November 2021 to March 2023, with confirmed acute SARS-CoV-2 infection. A telephone survey was conducted at 3-6-12 months after discharge.

resultsWe included 167 patients (77 F/90 M). Upon hospital admission, 95.5% of patients presented as symptomatic. Regarding patients for whom it was feasible to determine the SARS-CoV-2 variant (n = 51), the Delta variant was identified in 11 children (21.6%) and Omicron variant in the remaining 40 patients (78.4%: 27.5% BA.1 variant; 15% BA.2 variant; 57.5% BA.5 variant). 19 patients (16.5%) reported experiencing at least one symptom indicative of Long COVID (weight loss 31.6%, inappetence 26.3%, chronic cough 21.1%, fatigue 21.1%, and sleep disturbances, wheezing, abdominal pain and mood disorders 15.8%). In only 4 patients with Long COVID we could identified a specific SARS-CoV-2 variant (3 Omicron: 2 BA.1 and 1 BA.2; 1 Delta).

conclusionsthis study underscores that long COVID is a significant concern in the pediatric population. Our data reinforce the importance of continuously monitoring the impact of long-COVID in infants, children, and adolescents. A follow-up following SARS-CoV-2 infection is therefore advisable, with symptom investigation tailored to the patient's age.

Indexed as

Child, HospitalizedCOVID-19AdolescentChildHumansInfantItalyPost-Acute COVID-19 SyndromeProspective StudiesSARS-CoV-2ChildrenCOVIDHospitalizedInfectionLong COVIDLong-term effectsSARS-CoV-2

Identifiers

PMID38355648
PMCPMC10865522
OpenAlexW4391818190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.