Evidence map›Paper›PMID 38355632›Full record

ArticleNature communications2024

Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales.

Rhys T White, Matthew J Bull, Clare R Barker, Julie M Arnott, Mandy Wootton, Lim S Jones, Robin A Howe, Mari Morgan, Melinda M Ashcroft, Brian M Forde and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. A community-based One Health approach to the pandemic dynamics ofAntimicrobial agents and chemotherapy · 2026
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  9. Origin and development of twoMicrobial genomics · 2025
    Article
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  13. Genomic epidemiology of a novelFrontiers in cellular and infection microbiology · 2025
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Rhys T WhiteSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID 0000-0001-6620-758X
Matthew J BullMicrobiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff, CF10 3AX, United Kingdom.
Clare R BarkerMicrobiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff, CF10 3AX, United Kingdom.
Julie M ArnottHealthcare Associated Infection, Antimicrobial Resistance & Prescribing Programme (HARP), Public Health Wales, 2 Capital Quarter, Tyndall Street, Cardiff, Wales, CF10 4BZ, United Kingdom.
Mandy WoottonPublic Health Wales Microbiology, University Hospital of Wales, Cardiff, Wales, CF14 4XW, United Kingdom.
Lim S JonesPublic Health Wales Microbiology, University Hospital of Wales, Cardiff, Wales, CF14 4XW, United Kingdom.
Robin A HowePublic Health Wales Microbiology, University Hospital of Wales, Cardiff, Wales, CF14 4XW, United Kingdom.
Mari MorganHealthcare Associated Infection, Antimicrobial Resistance & Prescribing Programme (HARP), Public Health Wales, 2 Capital Quarter, Tyndall Street, Cardiff, Wales, CF10 4BZ, United Kingdom.ORCID 0000-0002-8546-6189
Melinda M AshcroftDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0001-9157-4533
Brian M FordeAustralian Infectious Disease Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID 0000-0002-2264-4785
Thomas R ConnorMicrobiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff, CF10 3AX, United Kingdom. connortr@cardiff.ac.uk.ORCID 0000-0003-2394-6504
Scott A BeatsonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia. s.beatson@uq.edu.au.ORCID 0000-0002-1806-3283
University Hospital of Wales · GBPublic Health Wales · GBThe University of Queensland · AUCardiff University · GBThe University of Melbourne · AU

Funding

Medical Research Council MR/L015080/1Wellcome Trust
6 · The paper itself

Abstract

Antibiotic resistance is a significant global public health concern. Uropathogenic Escherichia coli sequence type (ST)131, a widely prevalent multidrug-resistant clone, is frequently associated with bacteraemia. This study investigates third-generation cephalosporin resistance in bloodstream infections caused by E. coli ST131. From 2013-2014 blood culture surveillance in Wales, 142 E. coli ST131 genomes were studied alongside global data. All three major ST131 clades were represented across Wales, with clade C/H30 predominant (n = 102/142, 71.8%). Consistent with global findings, Welsh strains of clade C/H30 contain β-lactamase genes from the bla

Indexed as

BacteremiaEscherichia coli InfectionsEscherichia coli ProteinsAnti-Bacterial Agentsbeta-LactamasesCluster AnalysisDrug Resistance, Multiple, BacterialEscherichia coliGenomicsGenotypeHumansWalesAnti-Bacterial Agentsbeta-LactamasesEscherichia coli Proteins

Identifiers

PMID38355632
PMCPMC10866875
OpenAlexW4391808092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.