ArticleBMC biology2024
Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures.
Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026Review
- New neurons flatten social hierarchies.Scientific reports · 2026Article
- Going wild: prioritizing experimental models of rodent-borne viruses to decode zoonotic spillover and pandemic risk.Journal of virology · 2026Review
- A Novel Cooperative Behavior Assay in Rats Reveals Distinct Social Coordination Strategies of Increasing Complexity and Social Reciprocity Deficits in a Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Of mice and gender: considering gender norms in rodent models.Biology of sex differences · 2026Review
- The gut microbiome shapes social behaviour across animal species.Nature reviews. Microbiology · 2026Review
- Attenuation of social preference and alteration of cortical neurons following adolescent cerebellar nuclei perturbation.Molecular psychiatry · 2026Article
- The Sikkim mouse (bioRxiv : the preprint server for biology · 2025Article
- The mouse gut microbiota responds to predator odor and predicts host behavior.bioRxiv : the preprint server for biology · 2025Article
- Hidden in plain sound: the scientific potential of house mouse squeaks.Biology letters · 2025Review
- Article
- Vocal communication is seasonal in social groups of wild, free-living house mice.Proceedings. Biological sciences · 2025Article
- Ecological Realism Accelerates Epigenetic Aging in Mice.Aging cell · 2025Article
- Rates of female mouse ultrasonic vocalizations are low and are not modulated by estrous state during interactions with muted males.Scientific reports · 2025Article
- Information sharing within a social network is key to behavioral flexibility-Lessons from mice tested under seminaturalistic conditions.Science advances · 2025Article
- Competitive social feedback amplifies the role of early life contingency in male mice.Science (New York, N.Y.) · 2025Article
- Induction of territorial dominance and subordination behaviors in laboratory mice.Scientific reports · 2024Article
- Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Publisher Correction: Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures.BMC biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSocial behavior and social organization have major influences on individual health and fitness. Yet, biomedical research focuses on studying a few genotypes under impoverished social conditions. Understanding how lab conditions have modified social organizations of model organisms, such as lab mice, relative to natural populations is a missing link between socioecology and biomedical science.
resultsUsing a common garden design, we describe the formation of social structure in the well-studied laboratory mouse strain, C57BL/6J, in replicated mixed-sex populations over 10-day trials compared to control trials with wild-derived outbred house mice in outdoor field enclosures. We focus on three key features of mouse social systems: (i) territory establishment in males, (ii) female social relationships, and (iii) the social networks formed by the populations. Male territorial behaviors were similar but muted in C57 compared to wild-derived mice. Female C57 sharply differed from wild-derived females, showing little social bias toward cage mates and exploring substantially more of the enclosures compared to all other groups. Female behavior consistently generated denser social networks in C57 than in wild-derived mice.
conclusionsC57 and wild-derived mice individually vary in their social and spatial behaviors which scale to shape overall social organization. The repeatable societies formed under field conditions highlights opportunities to experimentally study the interplay between society and individual biology using model organisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.