Evidence map›Paper›PMID 38355565›Full record

ArticleThe international journal of behavioral nutrition and physical activity2024

Physical activity and sleep pattern in relation to incident Parkinson's disease: a cohort study.

Li-Hua Chen, Shi-Yu Sun, Guijie Li, Xiang Gao, Weifeng Luo, Haili Tian, Xuanhao Zhang, Xi Yin, Ziwei Liu, Guo-Chong Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of behavioral nutrition and physical activity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Li-Hua Chen *Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.ORCID 0000-0002-0839-3254
Shi-Yu Sun *Institute of Pain Medicine and Special Environmental Medicine, Nantong University, 9 Seyuan Road, Chongchuan District, 226019, Nantong, China.
Guijie LiDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Xiang GaoDepartment of Nutritional Sciences, The Pennsylvania State University, 16801, State College, PA, USA.
Weifeng LuoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Haili TianSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Xuanhao ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Xi YinDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Ziwei LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Guo-Chong ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Guangfei XuDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Tong LiuInstitute of Pain Medicine and Special Environmental Medicine, Nantong University, 9 Seyuan Road, Chongchuan District, 226019, Nantong, China. tongliu@ntu.edu.cn.
Fu-Rong LiSchool of Public Health and Emergency Management, Southern University of Science and Technology, 1088 Xueyuan Avenue, Fuguang community, Taoyuan Street, Nanshan District, Shenzhen, China. lifr@sustech.edu.cn.
Nantong University · CNSoochow University · CNPennsylvania State University · USShanghai University of Sport · CNSouthern University of Science and Technology · CN

Funding

National Natural Science Foundation of China 81870874, 82171229,
6 · The paper itself

Abstract

backgroundHow physical activity (PA) and different sleep traits and overall sleep pattern interact in the development of Parkinson's disease (PD) remain unknown.

objectiveTo prospectively investigate the joint associations of PA and sleep pattern with risk of PD.

methodsIncluded were 339,666 PD-free participants from the UK Biobank. Baseline PA levels were grouped into low (< 600 MET-mins/week), medium (600 to < 3000 MET-mins/week) and high (≥ 3000 MET-mins/week) according to the instructions of the UK Biobank. Healthy sleep traits (chronotype, sleep duration, insomnia, snoring, and daytime sleepiness) were scored from 0 to 5 and were categorized into "ideal sleep pattern" (≥ 3 sleep scores) and "poor sleep pattern" (0-2 sleep scores). Hazard ratios (HRs) and 95% confidence intervals (CIs) of PD were estimated by Cox proportional hazards models.

resultsDuring a median of 11.8 years of follow-up, 1,966 PD events were identified. The PD risk was lower in participants with high PA (HR = 0.73; 95% CI: 0.64, 0.84), compared to those with low PA; and participants with ideal sleep pattern also had a lower risk of PD (HR = 0.78; 95% CI: 0.69, 0.87), compared to those with poor sleep pattern. When jointly investigating the combined effect, participants with both high PA and ideal sleep pattern had the lowest risk of incident PD (HR = 0.55; 95% CI: 0.44, 0.69), compared to those with low PA and poor sleep pattern; notably, participants with high PA but poor sleep pattern also gained benefit on PD risk reduction (HR = 0.74; 95% CI: 0.55, 0.99).

conclusionsBoth high PA and ideal sleep pattern were independently associated with lower risk of developing PD, and those with both high PA level and ideal sleep pattern had the lowest risk. Our results suggest that improving PA levels and sleep quality may be promising intervention targets for the prevention of PD.

Indexed as

Parkinson DiseaseCohort StudiesExerciseHumansRisk FactorsRisk Reduction BehaviorSleepJoint associationParkinson’s diseasePhysical activitySleep patternUK Biobank

Identifiers

PMID38355565
PMCPMC10867998
OpenAlexW4391812988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.