Evidence map›Paper›PMID 38355483›Full record

ReviewJournal of translational medicine2024

Recent advances of m6A methylation in skeletal system disease.

Jianhui Liang, Qian Yi, Yang Liu, Jiachen Li, Zecheng Yang, Wei Sun, Weichao Sun

Open access · goldAbstract readReview
In one paragraph

Review in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. mMolecular medicine reports · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. KIAA1429-mediated MCellular & molecular biology letters · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jianhui LiangDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
Qian YiDepartment of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, 646099, Sichuan, China.
Yang LiuDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
Jiachen LiDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
Zecheng YangDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
Wei SunDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. 414464705@qq.com.
Weichao SunDepartment of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. weichaosunshine@163.com.ORCID 0000-0003-1646-8524
Shenzhen University Health Science Center · CNShantou University · CNSouthwest Medical University · CN

Funding

Natural Science Foundation of China 82003126Scientific Research Foundation of Southwest Medical University 2021ZKMS009Shenzhen High-level Hospital Construction Fund 1801024Shenzhen Science and Technology Projects JCYJ20210324103604013Sichuan Science and Technology Program 2022YFS0609
6 · The paper itself

Abstract

Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6A modifications play a crucial role in regulating biological processes of all kinds of diseases, such as malignancy. Recently studies have revealed that as the most abundant epigentic modification, m6A is involved in the progression of SSD. However, the function of m6A modification in SSD is not fully illustrated. Therefore, make clear the relationship between m6A modification and SSD pathogenesis might provide novel sights for prevention and targeted treatment of SSD. This article will summarize the recent advances of m6A regulation in the biological processes of SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis and osteoarthritis, and discuss the potential clinical value, research challenge and future prospect of m6A modification in SSD.

Indexed as

Bone NeoplasmsOsteoarthritisAdenineHumansMethylationRNA6-methyladenineAdenineRNAm6A modificationOsteoarthritisOsteoporosisOsteosarcomaRheumatoid arthritis

Identifiers

PMID38355483
PMCPMC10868056
OpenAlexW4391811181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.