Evidence map›Paper›PMID 38355406›Full record

ArticleBMC genomics2024

Single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of prion protein gene (PRNP) in Nigerian livestock species.

Adeniyi C Adeola, Semiu F Bello, Abdussamad M Abdussamad, Rahamon A M Adedokun, Sunday C Olaogun, Nasiru Abdullahi, Akanbi I Mark, Anyebe B Onoja, Oscar J Sanke, Godwin F Mangbon and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 4 countries.

Adeniyi C Adeola *State Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. chadeola@mail.kiz.ac.cn.
Semiu F Bello *Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, 510642, Guangzhou, China.
Abdussamad M Abdussamad *Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Bayero University, Kano, Nigeria.
Rahamon A M Adedokun *Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Sunday C OlaogunDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Nasiru AbdullahiDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria.
Akanbi I MarkMinistry of Agriculture and Rural Development, Secretariat, Ibadan, Nigeria.
Anyebe B OnojaDepartment of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oscar J SankeTaraba State Ministry of Agriculture and Natural Resources, Jalingo, Nigeria.
Godwin F MangbonDivision of Veterinary Office, Serti, Nigeria.
Jebi IbrahimDepartment of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Makurdi, Nigeria.
Philip M DawudaDepartment of Animal Science, Faculty of Agriculture, National University of Lesotho, Maseru, South Africa.
Adebowale E SalakoDepartment of Animal Science, Faculty of Agriculture, University of Ibadan, Ibadan, Nigeria.
Samia KdidiLivestock and Wildlife Laboratory, Institut des Régions Arides, Université de Gabes, Route El Djorf, Km 22.5, 4119, Medenine, Tunisia.
Mohamed Habib YahyaouiLivestock and Wildlife Laboratory, Institut des Régions Arides, Université de Gabes, Route El Djorf, Km 22.5, 4119, Medenine, Tunisia.
University of Ibadan · NGBayero University Kano · NGInstitut des Régions Arides · TNFederal Ministry of Agriculture and Rural Development · NGKunming Institute of Zoology · CNNational University of Lesotho · LSNational Veterinary Research Institute · NGSouth China Agricultural University · CNTaraba State University · NGUniversity of Agriculture · NG

Funding

The Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences The Large Research Infrastructure FundingThe Chinese Academy of Sciences President's International Fellowship Initiative (CAS-PIFI) 2021FYB0006The Sino-Africa Joint Research Center, Chinese Academy of Sciences SAJC202103
6 · The paper itself

Abstract

backgroundPrion diseases, also known as transmissible spongiform encephalopathies (TSEs) remain one of the deleterious disorders, which have affected several animal species. Polymorphism of the prion protein (PRNP) gene majorly determines the susceptibility of animals to TSEs. However, only limited studies have examined the variation in PRNP gene in different Nigerian livestock species. Thus, this study aimed to identify the polymorphism of PRNP gene in Nigerian livestock species (including camel, dog, horse, goat, and sheep). We sequenced the open reading frame (ORF) of 65 camels, 31 village dogs and 12 horses from Nigeria and compared with PRNP sequences of 886 individuals retrieved from public databases.

resultsAll the 994 individuals were assigned into 162 haplotypes. The sheep had the highest number of haplotypes (n = 54), and the camel had the lowest (n = 7). Phylogenetic tree further confirmed clustering of Nigerian individuals into their various species. We detected five non-synonymous SNPs of PRNP comprising of G9A, G10A, C11G, G12C, and T669C shared by all Nigerian livestock species and were in Hardy-Weinberg Equilibrium (HWE). The amino acid changes in these five non-synonymous SNP were all "benign" via Polyphen-2 program. Three SNPs G34C, T699C, and C738G occurred only in Nigerian dogs while C16G, G502A, G503A, and C681A in Nigerian horse. In addition, C50T was detected only in goats and sheep.

conclusionOur study serves as the first to simultaneously investigate the polymorphism of PRNP gene in Nigerian livestock species and provides relevant information that could be adopted in programs targeted at breeding for prion diseases resistance.

Indexed as

Prion DiseasesPrionsScrapieAnimalsCamelusDogsGoatsHorsesLivestockOpen Reading FramesPhylogenyPolymorphism, Single NucleotidePrion ProteinsSheepPrion ProteinsPrionsLivestockNigeriaPolymorphismPrion protein geneScrapieSusceptibility

Identifiers

PMID38355406
PMCPMC10865551
OpenAlexW4391814477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.