Evidence map›Paper›PMID 38355030›Full record

ArticleClinical immunology (Orlando, Fla.)2024

Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.

Elizabeth E Sloan, Katarina Kmetova, Somanathapura K NaveenKumar, Lyndsay Kluge, Emily Chong, Claire K Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Jeanine Baisch, Lynnette Walters and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Elizabeth E SloanDivision of Pediatric Rheumatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Scottish Rite for Children, Dallas, TX, USA; Children's Medical Center, Dallas, TX, USA.
Katarina KmetovaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Somanathapura K NaveenKumarDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Lyndsay KlugeDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Emily ChongDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Claire K HoyDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Srilakshmi YalavarthiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Cyrus SaroshDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jeanine BaischGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Lynnette WaltersScottish Rite for Children, Dallas, TX, USA.
Lorien NassiDivision of Pediatric Rheumatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Scottish Rite for Children, Dallas, TX, USA; Children's Medical Center, Dallas, TX, USA.
Julie FullerDivision of Pediatric Rheumatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Scottish Rite for Children, Dallas, TX, USA; Children's Medical Center, Dallas, TX, USA.
Jessica L TurnierDivision of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Virginia PascualGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Tracey B WrightDivision of Pediatric Rheumatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Scottish Rite for Children, Dallas, TX, USA; Children's Medical Center, Dallas, TX, USA.
Jacqueline A MadisonDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Jason S KnightDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Ayesha ZiaChildren's Medical Center, Dallas, TX, USA; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yu ZuoDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: yzu@umich.edu.
University of Michigan–Ann Arbor · USThe University of Texas Southwestern Medical Center · USChildren's Medical Center · USCornell University · USTexas Scottish Rite Hospital for Children · US

Funding

Purinergic modulation of the autoimmune vascular phenotypeR01HL134846 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 2018 to 2026
$4.8M
Functional Characterization of Children with Chronic Venous Thromboembolic DiseaseR01HL153963 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZIA, AYESHA · 2021 to 2024
$2.8M
Predicting and Preventing Poor Outcomes of Venous Thromboembolism in ChildrenK23HL132054 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZIA, AYESHA · 2016 to 2020
$876k
Thromboinflammatory consequences of infection-induced autoimmunityK08AR080205 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yu Zuo · 2022 to 2026
$865k
Functional Characterization of Children with Chronic Thromboembolic DiseaseR56HL153963 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZIA, AYESHA · 2020 to 2020
$704k
Harnessing cutaneous transcriptional and myeloid cell signatures to understand treatment response in juvenile dermatomyositisK23AR080789 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Leigh Turnier · 2023 to 2026
$693k
NHLBI NIH HHS K23 HL132054NHLBI NIH HHS R01 HL134846NHLBI NIH HHS R01 HL153963NHLBI NIH HHS R56 HL153963NIAMS NIH HHS K08 AR080205NIAMS NIH HHS K23 AR080789
6 · The paper itself

Abstract

Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prothrombin (aPS/PT) IgG (p < 0.001), and aPS/PT IgM (p < 0.001) were significantly associated with venous thrombosis. Positive anti-D1 IgG (p < 0.001), aPS/PT IgG (p < 0.001), and aPS/PT IgM (p = 0.001) were also associated with non-thrombotic manifestations of APS, such as thrombocytopenia. Increased levels of calprotectin were detected in children with APS. Calprotectin correlated positively with absolute neutrophil count (r = 0.63, p = 0.008) and negatively with platelet count (r = -0.59, p = 0.015). Mechanistically, plasma from pediatric APS patients with high calprotectin levels impaired platelet viability in a dose-dependent manner.

Indexed as

Antibodies, AntiphospholipidAntiphospholipid Syndromebeta 2-Glycoprotein IBiomarkersChildHumansImmunoglobulin GImmunoglobulin MLeukocyte L1 Antigen ComplexProthrombinAntibodies, Antiphospholipidbeta 2-Glycoprotein IBiomarkersImmunoglobulin GImmunoglobulin MLeukocyte L1 Antigen ComplexProthrombinAntiphospholipid syndromeCalprotectinNon-criteria antiphospholipid antibodiesPediatricThrombocytopenia

Identifiers

PMID38355030
PMCPMC11218031
OpenAlexW4391783133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.