SynthesisNeuroscience and biobehavioral reviews2024
BrainAGE, brain health, and mental disorders: A systematic review.
Synthesis in Neuroscience and biobehavioral reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.Schizophrenia bulletin · 2026Article
- Brain aging patterns among nine neurological disorders: A case-control study.PLoS medicine · 2026Article
- Depression and aging: insights from brain age prediction models.Psychological medicine · 2026Article
- The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women.Neuroscience · 2026Article
- Mortality of People With Alzheimer's Disease and Psychiatric Morbidity: A Nationwide Finnish Cohort Study.International journal of geriatric psychiatry · 2026Article
- Social and clinical frailty indices in aging mice: a comparative analysis of longitudinal and cross-sectional designs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neuroanatomical patterns of dementia risk in autism spectrum disorder.Frontiers in aging neuroscience · 2026Article
- Mapping Neurochemical Signatures onto Brain Structure for Neurotransmitter-Informed Discrimination of Schizophrenia Patients from Healthy Controls.medRxiv : the preprint server for health sciences · 2025Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
- Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health.Communications medicine · 2025Article
- Neuroanatomical features reveal accelerated brain age in alcohol use disorder.bioRxiv : the preprint server for biology · 2025Article
- [Research progress in electroencephalogram-based brain age prediction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Current challenges and future directions for brain age prediction in children and adolescents.Nature communications · 2025Review
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders.Biological psychiatry global open science · 2025Article
- Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.bioRxiv : the preprint server for biology · 2025Article
- Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.Frontiers in aging neuroscience · 2025Article
- A multimodal ensemble stacking model improves brain age prediction and reveals associations with schizophrenia symptoms.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The imaging-based method of brainAGE aims to characterize an individual's vulnerability to age-related brain changes. The present study systematically reviewed brainAGE findings in neuropsychiatric conditions and discussed the potential of brainAGE as a marker for biological age. A systematic PubMed search (from inception to March 6th, 2023) identified 273 articles. The 30 included studies compared brainAGE between neuropsychiatric and healthy groups (n≥50). We presented results qualitatively and adapted a bias risk assessment questionnaire. The imaging modalities, design, and input features varied considerably between studies. While the studies found higher brainAGE in neuropsychiatric conditions (11 mild cognitive impairment/ dementia, 11 schizophrenia spectrum/ other psychotic and bipolar disorder, six depression/ anxiety, two multiple groups), the associations with clinical characteristics were mixed. While brainAGE is sensitive to group differences, limitations include the lack of diverse training samples, multi-modal studies, and external validation. Only a few studies obtained longitudinal data, and all have used algorithms built solely to predict chronological age. These limitations impede the validity of brainAGE as a biological age marker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.