Evidence map›Paper›PMID 38354740›Full record

ArticleCell metabolism2024

SLC25A51 decouples the mitochondrial NAD

Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, Stefano Tiziani, Xiaolu A Cambronne

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  10. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
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  16. Cuproplasia and cuproptosis, two sides of the coin.Cancer communications (London, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mu-Jie LuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Jonathan BusquetsDepartment of Nutritional Sciences, College of Natural Sciences, University of Texas at Austin, Austin, TX, USA.
Valeria ImpedovoDepartment of Nutritional Sciences, College of Natural Sciences, University of Texas at Austin, Austin, TX, USA.
Crystal N WilsonDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Hsin-Ru ChanDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Yu-Tai ChangDepartment of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, USA; LIVESTRONG Cancer Institutes, University of Texas at Austin, Austin, TX, USA.
William MatsuiDepartment of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, USA; LIVESTRONG Cancer Institutes, University of Texas at Austin, Austin, TX, USA.
Stefano TizianiDepartment of Nutritional Sciences, College of Natural Sciences, University of Texas at Austin, Austin, TX, USA; Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA; Department of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, USA; LIVESTRONG Cancer Institutes, University of Texas at Austin, Austin, TX, USA.
Xiaolu A CambronneDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA; LIVESTRONG Cancer Institutes, University of Texas at Austin, Austin, TX, USA. Electronic address: lulu@austin.utexas.edu.
The University of Texas at Austin · USLivestrong Foundation · US

Funding

Therapeutic targeting of glutamine metabolism in MDSR01CA206210 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KONOPLEVA, MARINA Y, TIZIANI, STEFANO · 2016 to 2020
$2.4M
Gatekeepers of Mitochondrial NAD+DP2GM126897 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CAMBRONNE, XIAOLU ANG · 2017 to 2021
$2.4M
Mitochondrial NAD+ in Acute Myeloid LeukemiasR01CA272490 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI Xiaolu Ang Cambronne · 2023 to 2026
$2.1M
NCI NIH HHS R01 CA206210NCI NIH HHS R01 CA272490NIGMS NIH HHS DP2 GM126897
6 · The paper itself

Abstract

SLC25A51 selectively imports oxidized NAD

Indexed as

Leukemia, Myeloid, AcuteNADCell Line, TumorCell ProliferationHumansMitochondriaMitochondrial Membrane Transport ProteinsOxidation-ReductionMitochondrial Membrane Transport ProteinsNADSLC25A51 protein, humanAMLglutamine utilizationMCART1oxidative mitochondriaSLC25A51tumor metabolism

Identifiers

PMID38354740
PMCPMC10990793
OpenAlexW4391819209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.