Evidence map›Paper›PMID 38354120›Full record

ReviewEnvironmental science & technology2024

Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review.

Tyler A Jacobson, Yeunook Bae, Jasdeep S Kler, Ramsunder Iyer, Runze Zhang, Nathan D Montgomery, Denise Nunes, Joachim D Pleil, William E Funk

Open access · hybridAbstract readReview
In one paragraph

Review in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tyler A JacobsonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.ORCID 0000-0002-9655-1186
Yeunook BaeDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.ORCID 0000-0001-5580-9008
Jasdeep S KlerUniversity of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
Ramsunder IyerDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Runze ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Nathan D MontgomeryDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Denise NunesGalter Health Sciences Library, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Joachim D PleilDepartment of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
William E FunkDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Northwestern University · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · US

Funding

The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Protein Adducts as Measures of Exposure Throughout Childhood DevelopmentR21ES026776 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FUNK, WILLIAM E · 2016 to 2017
$432k
NIEHS NIH HHS R21 ES026776NIH HHS U24 OD023319
6 · The paper itself

Abstract

Mycotoxins are a heterogeneous group of toxins produced by fungi that can grow in staple crops (e.g., maize, cereals), resulting in health risks due to widespread exposure from human consumption and inhalation. Dried blood spot (DBS), dried serum spot (DSS), and volumetric tip microsampling (VTS) assays were developed and validated for several important mycotoxins. This review summarizes studies that have developed these assays to monitor mycotoxin exposures in human biological samples and highlights future directions to facilitate minimally invasive sampling techniques as global public health tools. A systematic search of PubMed (MEDLINE), Embase (Elsevier), and CINAHL (EBSCO) was conducted. Key assay performance metrics were extracted to provide a critical review of the available methods. This search identified 11 published reports related to measuring mycotoxins (ochratoxins, aflatoxins, and fumonisins) using DBS/DSS and VTS assays. Multimycotoxin assays adapted for DBS/DSS and VTS have undergone sufficient laboratory validation for applications in large-scale population health and human biomonitoring studies. Future work should expand the number of mycotoxins that can be measured in multimycotoxin assays, continue to improve multimycotoxin assay sensitivities of several biomarkers with low detection rates, and validate multimycotoxin assays across diverse populations with varying exposure levels. Validated low-cost and ultrasensitive minimally invasive sampling methods should be deployed in human biomonitoring and public health surveillance studies to guide policy interventions to reduce inequities in global mycotoxin exposures.

Indexed as

MycotoxinsEnvironmental MonitoringGlobal HealthHumansMycotoxinsaflatoxinsbiomonitoringdried blood spotsdried serum spotsfumonisinsmycotoxinsochratoxinsvolumetric tip microsampling

Identifiers

PMID38354120
PMCPMC10903514
OpenAlexW4391807760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.