Evidence map›Paper›PMID 38353893›Full record

ArticleBehavior genetics2024

Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study.

Susanne Bruins, Elsje van Bergen, Maurits W Masselink, Stefania A Barzeva, Catharina A Hartman, Roy Otten, Nanda N J Rommelse, Conor V Dolan, Dorret I Boomsma

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susanne BruinsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. s.bruins@vu.nl.
Elsje van BergenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Maurits W MasselinkBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Stefania A BarzevaBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Roy OttenBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Nanda N J RommelseDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Conor V DolanDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Funding

ZonMw 636340003
6 · The paper itself

Abstract

There is a negative association between intelligence and psychopathology. We analyzed data on intelligence and psychopathology to assess this association in seven-year-old Dutch twin pairs (ranging from 616 to 14,150 depending on the phenotype) and estimated the degree to which genetic and environmental factors common to intelligence and psychopathology explain the association. Secondly, we examined whether genetic and environmental effects on psychopathology are moderated by intelligence. We found that intelligence, as assessed by psychometric IQ tests, correlated negatively with childhood psychopathology, as assessed by the DSM-oriented scales of the Child Behavior Check List (CBCL). The correlations ranged between - .09 and - .15 and were mainly explained by common genetic factors. Intelligence moderated genetic and environmental effects on anxiety and negative affect, but not those on ADHD, ODD, and autism. The heritability of anxiety and negative affect was greatest in individuals with below-average intelligence. We discuss mechanisms through which this effect could arise, and we end with some recommendations for future research.

Indexed as

Autistic DisorderTwinsChildEuropean PeopleHumansIntelligencePsychopathologyRisk FactorsChildhood psychopathologyDevelopmental psychologyGene-environment interactionIntelligence

Identifiers

PMID38353893
PMCPMC11032279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.