Evidence map›Paper›PMID 38353885›Full record

ArticleEndocrine2024

Multiple bronchial carcinoids associated with Cowden syndrome.

Zsófia Tömböl, Judit Tőke, Géza Tóth, Zsolt Varga, Eszter Balázs, Erika Tóth, Lajos Gergely, Ľudovít Danihel, Márta Medvecz, Katalin Borka and 1 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Zsófia Tömböl *Department of Medicine and Oncology, ENETS Center of Excellence, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Judit Tőke *Department of Medicine and Oncology, ENETS Center of Excellence, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Géza TóthDepartment of Endocrinology, Szent Lázár County Hospital, Salgótarján, Hungary.
Zsolt VargaMedical Imaging Centre, Department of Nuclear Medicine, Semmelweis University, Budapest, Hungary.
Eszter BalázsMedical Imaging Centre, Department of Radiology, Semmelweis University, Budapest, Hungary.
Erika TóthNational Institute of Oncology, Department of Surgical and Molecular Pathology, Tumour Pathology Center, Budapest, Hungary.
Lajos GergelyInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, University Hospital Bratislava, Bratislava, Slovak Republic.
Ľudovít DanihelInstitute of Pathological Anatomy, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovak Republic.
Márta MedveczDepartment of Dermatology, Venereology and Dermatooncology, ERN-Skin HCP, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Katalin BorkaDepartment of Pathology, Forensic and Insurance Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Miklós TóthDepartment of Medicine and Oncology, ENETS Center of Excellence, Faculty of Medicine, Semmelweis University, Budapest, Hungary. toth.miklos@med.semmelweis-univ.hu.ORCID 0000-0002-8701-408X
Semmelweis University · HUComenius University Bratislava · SKNational Institute of Oncology · HUUniversity Hospital Bratislava · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cowden syndrome (CS) is a rare genetic condition due to the various germline mutations in the phosphatase and tensin homologue on chromosome ten (PTEN) tumour suppressor gene. As a result, CS is characterised by an increased risk of developing various benign and malignant tumours, such as thyroid, breast, endometrial and urogenital neoplasms, as well as gastrointestinal tract tumours. However, the neuroendocrine tumour association with CS is not elucidated yet. We present a case of a 46-year-old male patient diagnosed with testicular seminoma and follicular thyroid cancer in his medical history. Our patient met the clinical diagnostic criteria of Cowden syndrome. Genetic analysis established the clinical diagnosis; a known heterozygous PTEN mutation was detected [PTEN (LRG_311t1)c.388 C > T (p.Arg130Ter)]. Incidentally, he was also seen with multiple pulmonary lesions during his oncological follow-up. A video-assisted thoracoscopic left lingula wedge resection and later resections from the right lung were performed. Histological findings revealed typical pulmonary carcinoid tumours and smaller tumorlets. Somatostatin receptor SPECT-CT,

Indexed as

Carcinoid TumorHamartoma Syndrome, MultipleBronchial NeoplasmsHumansMaleMiddle AgedPTEN PhosphohydrolasePTEN PhosphohydrolasePTEN protein, humanCowden syndromeMultiple pulmonary carcinoidsPTEN mutation

Identifiers

PMID38353885
PMCPMC11208178
OpenAlexW4391817373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.