Evidence map›Paper›PMID 38353727›Full record

ArticleDiabetologia2024

Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data.

Pedro F Teixeira, Tadej Battelino, Anneli Carlsson, Soffia Gudbjörnsdottir, Ulf Hannelius, Matthias von Herrath, Mikael Knip, Olle Korsgren, Helena Elding Larsson, Anton Lindqvist and 9 more

Abstract read
In one paragraph

Article in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pedro F TeixeiraDiamyd Medical AB, Stockholm, Sweden.
Tadej BattelinoUniversity Medical Center Ljubljana, University of Ljubljana, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0002-0273-4732
Anneli CarlssonDepartment of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden.
Soffia GudbjörnsdottirSwedish National Diabetes Register, Centre of Registers, Gothenburg, Sweden.
Ulf HanneliusDiamyd Medical AB, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1562-437X
Matthias von HerrathGlobal Chief Medical Office, Novo Nordisk, A/S, Søborg, Denmark.
Mikael KnipResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0474-0033
Olle KorsgrenDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-8524-9547
Helena Elding LarssonDepartment of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden.ORCID http://orcid.org/0000-0003-3306-1742
Anton LindqvistDiamyd Medical AB, Stockholm, Sweden.
Johnny LudvigssonCrown Princess Victoria Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0003-1695-5234
Markus LundgrenDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0001-6394-7689
Christoph NowakDiamyd Medical AB, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8435-3978
Paul PetterssonDivision of Networked and Embedded Systems, Mälardalen University, Västerås, Sweden.
Flemming PociotSteno Diabetes Center Copenhagen, Herlev, Denmark.ORCID http://orcid.org/0000-0003-3274-5448
Frida SundbergDepartment of Paediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Karin ÅkessonDepartment of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Center, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0003-2556-5094
Åke LernmarkDepartment of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden. ake.lernmark@med.lu.se.ORCID http://orcid.org/0000-0003-1735-0499
Gun ForsanderDepartment of Paediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. gun.forsander@pediat.gu.se.ORCID http://orcid.org/0000-0002-0266-9651

Funding

VINNOVA 2021-02 684
6 · The paper itself

Abstract

The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effectiveness and acceptance at population level. Artificial intelligence (AI) has the potential to contribute to solving these issues, starting with the identification and stratification of at-risk individuals. ASSET (AI for Sustainable Prevention of Autoimmunity in the Society; www.asset.healthcare ) is a public/private consortium that was established to contribute to research around screening for type 1 diabetes and particularly to how AI can drive the implementation of a precision medicine approach to disease prevention. ASSET will additionally focus on issues pertaining to operational implementation of screening. The authors of this article, researchers and clinicians active in the field of type 1 diabetes, met in an open forum to independently debate key issues around screening for type 1 diabetes and to advise ASSET. The potential use of AI in the analysis of longitudinal data from observational cohort studies to inform the design of improved, more individualised screening programmes was also discussed. A key issue was whether AI would allow the research community and industry to capitalise on large publicly available data repositories to design screening programmes that allow the early detection of individuals at high risk and enable clinical evaluation of preventive therapies. Overall, AI has the potential to revolutionise type 1 diabetes screening, in particular to help identify individuals who are at increased risk of disease and aid in the design of appropriate follow-up plans. We hope that this initiative will stimulate further research on this very timely topic.

Indexed as

Artificial IntelligenceDiabetes Mellitus, Type 1Mass ScreeningHumansPrecision MedicineAIArtificial intelligenceASSETChildrenPrecision medicinePreventionScreeningType 1 diabetes

Identifiers

PMID38353727
PMCPMC11058797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.