Evidence map›Paper›PMID 38353724›Full record

ArticleFunctional & integrative genomics2024

LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma.

Dong Jin, Yongfeng Hui, Di Liu, Nan Li, Junzhi Leng, Genwang Wang, Qi Wang, Zhenhui Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  7. Inducing ferroptosis to improve cancer therapy: a promising tool for enhancing immunotherapy.Journal of experimental & clinical cancer research : CR · 2025
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  13. [Research progress on ferroptosis regulation in tumor immunity of hepatocellular carcinoma].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  14. Ferroptosis and the tumor microenvironment.Journal of experimental & clinical cancer research : CR · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dong Jin *Department of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Yongfeng Hui *Department of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Di Liu *Department of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Nan Li *Department of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Junzhi LengDepartment of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Genwang WangDepartment of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Qi WangDepartment of Hepatobiliary Surgery, Ningxia Medical University General Hospital, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China. wq-6562@163.com.
Zhenhui LuDepartment of Hepatobiliary Surgery, Shekou Shenzhen People's Hospital, 36 Shekou Industrial 7 Road, Nanshan District, Shenzhen, 518067, Guangdong, China. zhenhuilu@hotmail.com.
Ningxia Medical University · CNNingxia Medical University General Hospital · CNShenzhen Sixth People's Hospital · CN

Funding

Key R&D Program of Ningxia Autonomous Region 2021BEG03067Natural Science Foundation of Ningxia Province 2022AAC03545Ningxia Hui Autonomous Region Science and Technology Project 2021CMG03015
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor with a high recurrence rate and a poor prognosis. Long intergenic nonprotein coding RNA 942 (LINC00942) is reported to be related to ferroptosis and the immune response in HCC and serves as an oncogene in various cancers. This research aimed to explore the contribution of LINC00942 in HCC progression. Functional assays were used to evaluate the functional role of LINC00942 in vitro and in vivo. Mechanistic assays were conducted to assess the association of LINC00942 with insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) and solute carrier family 7 member 11 (SLC7A11) and the regulatory pattern of LINC00942 in HCC cells. LINC00942 was found to exhibit upregulation in HCC tissue and cells. LINC00942 facilitated HCC cell proliferation, suppressed ferroptosis, and converted naive CD4

Indexed as

Carcinoma, HepatocellularFerroptosisLiver NeoplasmsAnimalsImmunosuppression TherapyMiceT-Lymphocytes, RegulatoryFerroptosisHepatocellular carcinoma (HCC)IGF2BP3LINC00942SLC7A11

Identifiers

PMID38353724
PMCPMC10867055
OpenAlexW4391824927

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.