Evidence map›Paper›PMID 38353560›Full record

ArticlemBio2024

Bacteriophage and antibiotic combination therapy for recurrent

Madison E Stellfox, Carolyn Fernandes, Ryan K Shields, Ghady Haidar, Kailey Hughes Kramer, Emily Dembinski, Mihnea R Mangalea, Garima Arya, Gregory S Canfield, Breck A Duerkop and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07275905 (A Phase 1, Open-label, Randomized, Pilot and Feasibility Trial to Evaluate the Safety and Tolerability of the Achromobacter-targeting Bacteriophage Cocktail, AchromoPhage, Among Persons With Cystic Fibrosis and Chronic Achromobacter Lung Infections), which is not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07275905 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase 1, Open-label, Randomized, Pilot and Feasibility Trial to Evaluate the Safety and Tolerability of the Achromobacter-targeting Bacteriophage Cocktail, AchromoPhage, Among Persons With Cystic Fibrosis and Chronic Achromobacter Lung Infections: The AchromoPhage Trial

TypeinterventionalSponsorGhady HaidarRan2026 to 2028Enrolled12ConditionsCystic Fibrosis (CF), Achromobacter InfectionArmsAchromoPhage
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Characterization ofPHAGE (New Rochelle, N.Y.) · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Journal of bacteriology · 2025
    Article
  16. The future of phage therapy in the USA.Trends in molecular medicine · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Madison E StellfoxDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1478-5190
Carolyn FernandesDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ryan K ShieldsDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9794-5665
Ghady HaidarDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0634-8211
Kailey Hughes KramerDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Emily DembinskiDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mihnea R MangaleaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Garima AryaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Gregory S CanfieldDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Breck A DuerkopDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-4030-9822
Daria Van TyneDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7284-0103
University of Pittsburgh · USUniversity of Colorado Denver · US

Funding

Enhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6M
Research Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1M
Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.R01AI141479 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DUERKOP, BRECK A · 2018 to 2025
$4.4M
Adaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0M
University of Pittsburgh Training Program in Antimicrobial ResistanceT32AI138954 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2019 to 2023
$971k
The Gut Microbiome in Carbapenem-Resistant Enterobacteriaceae Colonization, Persistence, Infection, and Tolerance after Lung or Liver TransplantationK23AI154546 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAIDAR, GHADY · 2021 to 2025
$896k
Use of site-specific pharmacokinetics to optimize antibiotic combinations and prevent the emergence of resistance against CRER21AI151363 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2021 to 2022
$431k
NIAID NIH HHS K23 AI154546NIAID NIH HHS R01 AI127472NIAID NIH HHS R01 AI141479NIAID NIH HHS R01 AI165519NIAID NIH HHS R21 AI151363NIAID NIH HHS T32 AI138954NIAMS NIH HHS T32 AR007534
6 · The paper itself

Abstract

IMPORTANCE: Phage therapy is an emerging therapeutic approach for treating bacterial infections that do not respond to traditional antibiotics. The addition of phage therapy to systemic antibiotics to treat a patient with recurrent

Indexed as

BacteremiaBacteriophagesEnterococcus faeciumGram-Positive Bacterial InfectionsVancomycin-Resistant EnterococciAnti-Bacterial AgentsEnterococcusHumansMicrobial Sensitivity TestsQuality of LifeAnti-Bacterial Agentsbacteriophage therapyphage-neutralizing antibodiesvancomycin-resistant Enterococcus faecium

Identifiers

PMID38353560
PMCPMC10936196
OpenAlexW4391811865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.