Evidence map›Paper›PMID 38353324›Full record

Trial reportHead & neck2024

Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685.

Christopher S Hollenbeak, Fenghai Duan, Rathan M Subramaniam, Alexander Taurone, JoRean Sicks, Val J Lowe, Brendan C Stack

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & neck, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Possible Clinical Predictors for Dysphagia in Head and Neck Cancer Patients after Surgery.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Christopher S HollenbeakDepartment of Health Policy and Administration, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-3362-814X
Fenghai DuanDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Rathan M SubramaniamFaculty of Medicine, Nursing, Midwifery and Health Sciences, University of Notre Dame Australia, Sydney, Australia.
Alexander TauroneDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
JoRean SicksDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Brendan C StackDepartment of Otolaryngology - Head Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Brown University · USDuke University · USMayo Clinic · USPennsylvania State University · USSouthern Illinois University School of Medicine · US

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6M
Statistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO · 2014 to 2026
$111.2M
Biostatistics Data Management Center for ACRINU10CA079778 · NCI · BROWN UNIVERSITY · PI GATSONIS, CONSTANTINE A. · 2013 to 2013
$2.4M
ECOG-ACRIN Cancer Research Group U10CA079778ECOG-ACRIN Cancer Research Group U10CA180794ECOG-ACRIN Cancer Research Group U10CA180820ECOG-ACRIN Cancer Research Group UG1CA18982NCI NIH HHS U10 CA079778NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180820NCI NIH HHS UG1 CA189828
6 · The paper itself

Abstract

backgroundThis study examined the trajectory of health-related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s).

methodsHRQoL of 230 patients in the ACRIN 6685 trial was measured prospectively up to 2 years following surgery using the University of Washington Quality of Life instrument.

resultsGeneral Health Within the Last 7 Days did not differ significantly from baseline at any follow-up. General Health Relative to Before Cancer fell significantly by 5.8 points following surgery (p = 0.048), and then returned to 3.0 points above baseline at 1 year (p = 0.65). For Overall Quality of Life, HRQoL fell significantly by 4.3 points following surgery (p = 0.031) and then returned to levels not significantly different from baseline.

conclusionsPatients with stage N0 HNSCC experience significant declines in HRQoL immediately following surgery, including neck dissection, which recovers to near or better than baseline within 1-2 years.

Indexed as

Head and Neck NeoplasmsNeck DissectionQuality of LifeAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingProspective StudiesSquamous Cell Carcinoma of Head and NeckACRIN 6685clinical trialhead and neck squamous cell carcinomahealth‐related quality of lifelongitudinal studyneck dissection

Identifiers

PMID38353324
PMCPMC11227398
OpenAlexW4391822543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.