ReviewJournal of the American Heart Association2024
Role of Cognitive Frailty in Older Adults With Cardiovascular Disease.
Review in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Prevalence of cognitive frailty, reversible and potentially reversible cognitive frailty among older adults without dementia: a systematic review and meta-analysis.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Pooled it
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Dual-task training and cognitive performance in individuals with coronary artery disease and/or heart failure: a systematic review.Frontiers in cardiovascular medicine · 2025Pooled it
- Optimizing frailty care: an analysis of dual exercise targets and cognitive function among frail older adults.GeroScience · 2026Article
- The association of self- and interviewer-reported cognitive problems with frailty progression and subsequent all-cause mortality risk: a large-scale cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Multidimensional Frailty and Resilience in Relation to Quality of Life in Senior Patients with Cardiovascular Disease: An Exploratory Cross-Sectional Pilot Study.Journal of clinical medicine · 2026Article
- Review
- The Living Lab Concept in the Detection, Prevention and Monitoring of Geriatric Syndromes in Elderly Patients with Cardiovascular Disease-A Narrative Review.Journal of clinical medicine · 2026Review
- Peripheral CD8⁺ T cell subsets and physical frailty in community-dwelling older Thai adults: the role of age and multimorbidity.BMC geriatrics · 2026Article
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- EuroSCORE II: Current limitations and physiological gaps in risk stratification.Experimental physiology · 2026Review
- Prediction Model for Frailty in Middle-Aged and Older Adults with Cardiovascular Disease.Vascular health and risk management · 2026Article
- Optimal Management of HFpEF in Very Old Patients: Where Do We Stand?JACC. Heart failure · 2025Article
- Fazekas score predicts cognitive decline & frailty in older adults: insights from the SAGE-AF cohort study.Neurological research and practice · 2025Article
- Geriatric cognitive frailty and short-term prognosis following hip fracture surgery.BMC geriatrics · 2025Observational
- The relationship between cognitive impairment and quality of life in rural older adults with chronic diseases-parallel mediating effects of depressive symptoms and frailty.BMC geriatrics · 2025Article
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Healthy ageing in older adults with cardiovascular disease.European heart journal · 2025Review
- The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025Review
- Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.Journal of the American Heart Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
As the older adult population expands, an increasing number of patients affected by geriatric syndromes are seen by cardiovascular clinicians. One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve. Driven by common pathophysiologic underpinnings (eg, inflammation and neurohormonal dysregulation), cardiovascular disease, cognitive impairment, and frailty also share the following risk factors: hypertension, diabetes, obesity, sedentary behavior, and tobacco use. Cardiovascular disease has been associated with the onset and progression of cognitive frailty, which may be reversible in early stages, making it essential for clinicians to diagnose the condition in a timely manner and prescribe appropriate interventions. Additional research is required to elucidate the mechanisms underlying the development of cognitive frailty, establish preventive and therapeutic strategies to address the needs of older patients with cardiovascular disease at risk for cognitive frailty, and ultimately facilitate targeted intervention studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.