SynthesisEuropean stroke journal2024
Case fatality and functional outcome after spontaneous subarachnoid haemorrhage: A systematic review and meta-analysis of time trends and regional variations in population-based studies.
Synthesis in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Flow diverter treatment for saccular unruptured intracranial aneurysms: A systematic review focussing on study quality and initial outcomes.European stroke journal · 2026Pooled it
- Remote Ischemic Post-Conditioning Preserves the Neurovascular Unit by Brain-Derived Gas6 That Drives Monocyte-Derived Macrophage Reprogramming via Axl and Vimentin after SAH.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Active Cerebrospinal Fluid Exchange Versus External Ventricular Drainage in IVH and SAH: A Meta-Analysis.Stroke (Hoboken, N.J.) · 2026Article
- Sex disparities in case fatality rate after aneurysmal subarachnoid haemorrhage: a prospective longitudinal population-based cohort study.European stroke journal · 2026Article
- Variations across Europe in National Guidelines and Clinical Practice Regarding Screening of Cognitive and Emotional Consequences after Aneurysmal Subarachnoid Hemorrhage.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Impact of ABO Blood Group on Vascular Complications and on Clinical and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.Neurology international · 2026Article
- The genetics of the circle of Willis come full circle.European journal of human genetics : EJHG · 2026Article
- Natural killer cells and regulatory T cells in aneurysmal subarachnoid hemorrhage in peripheral blood and cerebrospinal fluid - a pilot study.Fluids and barriers of the CNS · 2026Observational
- Mechanical behavior of functionally zoned hybrid intracranial stent integrating laser-cut and braided architectures.Frontiers in bioengineering and biotechnology · 2026Article
- Incidence, risk factors, clinical and cognitive impact of secondary hemorrhage after spontaneous aneurysmal subarachnoid hemorrhage.Brain & spine · 2026Article
- Eighteen-Year Trends in Subarachnoid Hemorrhage Management and Outcomes: A Single-Center Experience.Neurocritical care · 2025Observational
- Flow diverter treatment for saccular unruptured intracranial aneurysms: A systematic review focussing on study quality and initial outcomes.European stroke journal · 2025Article
- Resource use and in-hospital costs after aneurysmal subarachnoid hemorrhage in the Netherlands.Brain & spine · 2025Article
- Modifiable Risk Factors for Subarachnoid Hemorrhage: Narrative Review With an Emphasis on Common Controversies and Epidemiologic Pitfalls.Neurology · 2024Review
- Trajectory of mean platelet volume changes after aneurysmal subarachnoid hemorrhage in patients with or without delayed cerebral ischemia.Scientific reports · 2024Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA previous systematic review of population-based studies from 1973 to 2002 found a decrease in case fatality for spontaneous subarachnoid haemorrhage, but could not find a sufficient number of studies to assess changes in functional outcome. Since then, treatment has advanced distinctly. We assessed whether case fatality has decreased further and whether functional outcome has improved. PATIENTS AND
methodsWe searched PubMed and Web of Science for new population-based studies using the same criteria as in our previous systematic review. We assessed changes in case fatality and functional outcome over time using linear regression.
resultsWe included 24 new studies with 827 patients and analysed 9542 patients described in 62 study periods between 1973 and 2017. Case fatality decreased by 0.3% (95% CI: -0.7 to 0.1) per year. In a sensitivity analysis excluding studies that did not provide 1-month outcome and outliers, the age and sex-adjusted decrease was 0.1% per year (95% CI: -0.9 to 0.6). The mean case fatality rate decreased from 47% (95% CI: 31-63) in the 1970s to 35% (95% CI: 30-39) in the 1990s, and remained stable in the 2000s (34%; 95% CI: 27-41) and 2010s (38%; 95% CI: 15-60). In 15 studies, the mean proportion of patients living independently increased by 0.2% per year (95%CI: -0.7 to 1.1) and the mean was 45% (95% CI: 39-50) in six studies that reported outcome after 12 months. DISCUSSION AND
conclusionFrom 1973 to 2017, the case-fatality rate of spontaneous subarachnoid haemorrhage declined overall by 13.5%, but remained stable over the last two decades. The data on time trends in functional outcome were inconclusive.
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