Evidence map›Paper›PMID 38353177›Full record

ArticlePediatric pulmonology2024

Acute exposure to pollen and airway inflammation in adolescents.

Nicholas J Nassikas, Heike Luttmann-Gibson, Sheryl L Rifas-Shiman, Emily Oken, Diane R Gold, Mary B Rice

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric pulmonology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Association of Short-Term Pollen Exposure With Lung Function in COPD Patients.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
  2. Development of the Respiratory System During Adolescence.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nicholas J NassikasBeth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-0798-3703
Heike Luttmann-GibsonDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-1265-9190
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School, Division of Chronic Disease Research Across the Lifecourse, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-0033-920X
Emily OkenDepartment of Population Medicine, Harvard Medical School, Division of Chronic Disease Research Across the Lifecourse, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-2513-3339
Diane R GoldDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-8789-418X
Mary B RiceBeth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-2538-391X
Harvard University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD034568NICHD NIH HHS R01HD034568NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIEHS NIH HHS R24 ES030894NIEHS NIH HHS R24ES030894NIH HHS UG3 OD023286NIH HHS UH3 OD023286NIH HHS UH3OD023286
6 · The paper itself

Abstract

introductionPollen exposure is known to exacerbate allergic asthma and allergic rhinitis symptoms, yet few studies have investigated if exposure to pollen affects lung function or airway inflammation in healthy children.

methodsWe evaluated the extent to which higher pollen exposure was associated with differences in airway inflammation and lung function among 490 early adolescent participants (mean age of 12.9 years) in Project Viva, a prebirth cohort based in Massachusetts. We obtained regional daily total pollen counts, including tree, grass, and weed pollen, from a Rotorod pollen counter. We evaluated associations of 3- and 7-day moving averages of pollen with fractional exhaled nitric oxide (FeNO) and lung function using linear regression models and evaluated the linearity of associations with penalized splines. We tested if associations of pollen with FeNO and lung function were modified by current asthma diagnosis, history of allergic rhinitis, aeroallergen sensitivity, temperature, precipitation, and air pollution.

resultsThree- and 7-day median pollen concentrations were 19.0 grains/m

conclusionShort-term exposure to pollen was associated with higher FeNO in early adolescents, even in the absence of allergic sensitization and asthma.

Indexed as

AsthmaNitric OxidePollenAdolescentAllergensBreath TestsChildEnvironmental ExposureFemaleHumansMaleMassachusettsRhinitis, Allergic, SeasonalAllergensNitric Oxideaeroallergenasthmaclimate changeexhaled nitric oxidelung function

Identifiers

PMID38353177
PMCPMC11058013
OpenAlexW4391822328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.