Evidence map›Paper›PMID 38353029›Full record

ArticleThe American journal of sports medicine2024

Detrimental Effects of Chlorhexidine on Articular Cartilage Viability, Matrix, and Mechanics.

Maziar Moslehyazdi, Benjamin Bielajew, John A Schlechter, Jerry C Hu, Kyriacos A Athanasiou, Dean Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. [Wound care following dermatologic surgical procedures].Dermatologie (Heidelberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maziar MoslehyazdiDepartment of Orthopaedic Surgery, University of California, Irvine, Orange, California, USA.
Benjamin BielajewDepartment of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.
John A SchlechterPediatric Orthopedic Specialists Orange County, Children's Hospital of Orange County, Orange, California, USA.ORCID 0000-0001-8389-8407
Jerry C HuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.ORCID 0000-0001-5387-8405
Dean WangDepartment of Orthopaedic Surgery, University of California, Irvine, Orange, California, USA.ORCID 0000-0002-3005-1154
University of California, Irvine · USChildren's Hospital of Orange County · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

backgroundChlorhexidine gluconate (CHG) solution is commonly used as an antiseptic irrigation for bacterial decontamination during orthopaedic surgery. Although the chondrotoxicity of CHG on articular cartilage has been reported, the full extent of CHG-related chondrotoxicity and its effects on the extracellular matrix and mechanical properties are unknown. PURPOSE: To investigate the in vitro effects of a single 1-minute CHG exposure on the viability, biochemical content, and mechanics of native articular cartilage explants. STUDY

designControlled laboratory study.

methodsArticular cartilage explants (6 per group) were harvested from femoral condyles of the porcine stifle and sectioned at tidemark. Explants were bathed in CHG solution (0.05% CHG in sterile water) at varying concentrations (0% control, 0.01% CHG, and 0.05% CHG) for 1 minute, followed by complete phosphate-buffered saline wash and culture in chondrogenic medium. At 7 days after CHG exposure, cell viability, matrix content (collagen and glycosaminoglycan [GAG]), and compressive mechanical properties (creep indentation testing) were assessed.

resultsOne-minute CHG exposure was chondrotoxic to explants, with both 0.05% CHG (2.6% ± 4.1%) and 0.01% CHG (76.3% ± 8.6%) causing a decrease in chondrocyte viability compared with controls (97.5% ± 0.6%;

conclusionOne-minute exposure to CHG for articular cartilage explants led to dose-dependent decreases in chondrocyte viability, GAG content, and compressive mechanical properties. This raises concern for the risk of mechanical failure of the cartilage tissue after CHG exposure. CLINICAL RELEVANCE: Clinicians should be judicious regarding the use of CHG irrigation at these concentrations in the presence of native articular cartilage.

Indexed as

Cartilage, ArticularAnimalsChlorhexidineChondrocytesCollagenGlycosaminoglycansSwineChlorhexidineCollagenGlycosaminoglycanscartilagechlorhexidinemechanicsviability

Identifiers

PMID38353029
PMCPMC10943607
OpenAlexW4391821381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.