Evidence map›Paper›PMID 38352884›Full record

ArticleFrontiers in immunology2024

Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys.

Katharina Schmalkuche, Tamina Rother, Sevval Besli, Reinhard Schwinzer, Rainer Blasczyk, Björn Petersen, Constanca Figueiredo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katharina SchmalkucheInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Tamina RotherInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Sevval BesliInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Reinhard SchwinzerTransregional Collaborative Research Centre 127, Hannover Medical School, Hannover, Germany.
Rainer BlasczykInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Björn PetersenTransregional Collaborative Research Centre 127, Hannover Medical School, Hannover, Germany.
Constanca FigueiredoInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xenotransplantation offers a promising alternative to circumvent the lack of donated human organs available for transplantation. Different attempts to improve the survival of xenografts led to the generation of transgenic pigs expressing various combinations of human protective genes or knocked out for specific antigens. Currently, testing the efficiency of porcine organs carrying different genetic modifications in preventing xenogeneic immune responses completely relies on

Indexed as

B7-H1 AntigenCD8-Positive T-LymphocytesAnimalsAnimals, Genetically ModifiedEndothelial CellsHumansKidneyLymphocyte ActivationMiceReproducibility of ResultsSwineB7-H1 Antigenex vivo organ perfusiongenetic engineeringkidney transplantationprogrammed cell death-1 ligand 1 (PD-L1)T-cell immune responsexenotransplantation

Identifiers

PMID38352884
PMCPMC10861674

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.