Evidence map›Paper›PMID 38352866›Full record

ArticleFrontiers in immunology2024

Razan M Alajoleen, David N Oakland, Rana Estaleen, Aida Shakeri, Ran Lu, Michael Appiah, Sha Sun, Jonathan Neumann, Shimako Kawauchi, Thomas E Cecere and 3 more

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

  • Retraction · 2024-07-03Concerns/Issues about Data · Concerns/Issues about Image · Investigation by Journal/Publisher · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Razan M AlajoleenDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
David N OaklandGraduate Program of Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Rana EstaleenDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Aida ShakeriDepartment of Biological Sciences, College of Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Ran LuDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Michael AppiahDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Sha SunDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Jonathan NeumannTransgenic Mouse Facility, University of California, Irvine, Irvine, CA, United States.
Shimako KawauchiTransgenic Mouse Facility, University of California, Irvine, Irvine, CA, United States.
Thomas E CecereDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Ryan P McMillanDepartment of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Christopher M ReillyDepartment of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States.
Xin M LuoDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Virginia Tech · USVirginia–Maryland College of Veterinary Medicine · USUniversity of California, Irvine · USEdward Via College of Osteopathic Medicine · US

Funding

Leaky gut drives autoimmunity via bacterial flagellin-mediated activation of TLR5R21AI156197 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LUO, XIN · 2021 to 2022
$420k
NIAID NIH HHS R21 AI156197
6 · The paper itself

Abstract

Introduction: Leaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus through bacterial flagellin-mediated activation of toll-like receptor 5 (TLR5). Methods: We created MRL/ Result: Contrary to our hypothesis that the deletion of Conclusion: Global deletion of

Indexed as

GlomerulonephritisToll-Like Receptor 5AnimalsFemaleHumansKidneyMiceMice, Inbred MRL lprProteinuriaTlr5 protein, mouseToll-Like Receptor 5glomerulonephritisgut microbiotalupuslymphoproliferationTLR5

Identifiers

PMID38352866
PMCPMC10862078
OpenAlexW4391353770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.