Evidence map›Paper›PMID 38352829›Full record

ArticleACS medicinal chemistry letters2024

Selective (α)-l-Rhamnosylation and Neuroprotective Activity Exploration of Cardiotonic Steroids.

Ryan Rutkoski, Lucas Kniess Debarba, Lukas Stilgenbauer, Tay Rosenthal, Marianna Sadagurski, Pavel Nagorny

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ryan RutkoskiDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Lucas Kniess DebarbaDepartment of Biological Sciences, Institute of Environmental Health Sciences, Integrative Biosciences Center, Wayne State University, Detroit, Michigan 48202, United States.
Lukas StilgenbauerDepartment of Biological Sciences, Institute of Environmental Health Sciences, Integrative Biosciences Center, Wayne State University, Detroit, Michigan 48202, United States.
Tay RosenthalSmall Molecule Discovery & Development, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States.
Marianna SadagurskiDepartment of Biological Sciences, Institute of Environmental Health Sciences, Integrative Biosciences Center, Wayne State University, Detroit, Michigan 48202, United States.
Pavel NagornyDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-7043-984X
Wayne State University · USUniversity of Michigan · USCorteva (United States) · US

Funding

Research Experience & Training Coordination CoreP42ES030991 · NIEHS · WAYNE STATE UNIVERSITY · PI Glen Ray Hood · 2022 to 2026
$13.9M
Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
New Methods and Strategies for the Synthesis and Selective Derivatization of Natural ProductsR35GM136341 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pavel Nagorny · 2020 to 2026
$2.6M
Canagliflozin as a Neuroprotective Agent to Improve Neuroinflammation and Cognitive Function during AgingRF1AG078170 · NIA · WAYNE STATE UNIVERSITY · PI Marianna Sadagurski · 2023 to 2026
$2.0M
Benzene exposure promotes neuroinflammation and metabolic dysregulationR01ES033171 · NIEHS · WAYNE STATE UNIVERSITY · PI Marianna Sadagurski · 2022 to 2026
$1.9M
NIA NIH HHS RF1 AG078170NIEHS NIH HHS P30 ES020957NIEHS NIH HHS P42 ES030991NIEHS NIH HHS R01 ES033171NIGMS NIH HHS R35 GM136341
6 · The paper itself

Abstract

This work describes the studies on the direct C3-glycosylation of the C19-hydroxylated cardiotonic steroids strophanthidol,

Identifiers

PMID38352829
PMCPMC10860192
OpenAlexW4390671898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.