Evidence map›Paper›PMID 38352661›Full record

ReviewMedical cannabis and cannabinoids

Cannabidiol-Derived Cannabinoids: The Unregulated Designer Drug Market Following the 2018 Farm Bill.

Charles N Zawatsky, Sara Mills-Huffnagle, Corinne M Augusto, Kent E Vrana, Jennifer E Nyland

Open access · goldAbstract readReview
In one paragraph

Review in Medical cannabis and cannabinoids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Correlates of Derived Cannabis Product Awareness, Knowledge, Use, and Use Intentions Among Young Adults.Health education & behavior : the official publication of the Society for Public Health Education · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Genotoxic assessment of aPharmaceutical biology · 2025
    Article
  9. Review
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charles N ZawatskyDepartment of Neural and Behavioral Sciences, Hershey, PA, USA.
Sara Mills-HuffnagleDepartment of Neural and Behavioral Sciences, Hershey, PA, USA.
Corinne M AugustoDepartment of Neural and Behavioral Sciences, Hershey, PA, USA.
Kent E VranaDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Jennifer E NylandDepartment of Neural and Behavioral Sciences, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · US

Funding

AI-based Mapping of Complex Cannabis Extracts in Pain PathwaysR01AT012053 · NCCIH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Nikolay Dokholyan, KENT E VRANA · 2023 to 2026
$2.4M
NCCIH NIH HHS R01 AT012053
6 · The paper itself

Abstract

Background: In this review, we summarize current scientific knowledge on psychoactive cannabinoids synthesized from cannabidiol (CBD) and sold in the semi-legal market established in response to the passage of the US Agriculture Improvement Act of 2018, commonly known as the 2018 Farm Bill. The discussion focuses on recent developments that suggest this unregulated market may be fertile ground for a potential health crisis. Summary: Current research into CBD-derived cannabinoids is mainly limited to Δ Key Messages: The CBD-derived cannabinoid market is growing internationally, and the market has diversified to include potent synthetic cannabinoids. The products sold on this unregulated market are under-researched despite growing availability and consumer interest. Ernest investigation of the pharmacology of these novel cannabinoids and the contents of CBD-derived cannabinoid products is critical for monitoring this potential source of another vaping-related epidemic.

Indexed as

Delta-8-tetrahydrocannabinolHexahydroxycannabiphorolKeteneO-acetyl-trahydrocannabinol-OTetrahydrocannabiphorol

Identifiers

PMID38352661
PMCPMC10864014
OpenAlexW4391771426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.