Evidence map›Paper›PMID 38352618›Full record

ArticlebioRxiv : the preprint server for biology2024

The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links.

Maria Altshuller, Xu He, Elliot J MacKrell, Kevin M Wernke, Joel W H Wong, Selene Sellés-Baiget, Ting-Yu Wang, Tsui-Fen Chou, Julien P Duxin, Emily P Balskus and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Maria AltshullerDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Xu HeDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Elliot J MacKrellDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Kevin M WernkeDepartment of Chemistry, Yale University, New Haven, CT, USA.
Joel W H WongDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Selene Sellés-BaigetTheNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ting-Yu WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tsui-Fen ChouDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Julien P DuxinTheNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USA.
Daniel R SemlowDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
California Institute of Technology · USUniversity of Copenhagen · DKYale University · USHarvard University · USHoward Hughes Medical Institute · US

Funding

Structural and functional studies of colibactinR01CA215553 · NCI · YALE UNIVERSITY · PI Seth B. Herzon, Christian Jobin · 2018 to 2026
$5.5M
Understanding the Mechanism of a Gut Microbial Genotoxin Involved in Colorectal CarcinogenesisR01CA208834 · NCI · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2016 to 2025
$3.7M
Supplement: Emerging Mechanisms of Replication-coupled DNA RepairR01GM151410 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Daniel Semlow · 2023 to 2026
$1.4M
NCI NIH HHS R01 CA208834NCI NIH HHS R01 CA215553NIGMS NIH HHS R01 GM151410
6 · The paper itself

Abstract

Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the progression of colorectal cancer and inflammatory bowel disease. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links (ICLs) that block DNA replication. While cells have evolved multiple mechanisms to resolve ("unhook") ICLs encountered by the replication machinery, little is known about which of these pathways promote resistance to colibactin-induced ICLs. Here, we use

Identifiers

PMID38352618
PMCPMC10862771
OpenAlexW4391388622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.