Evidence map›Paper›PMID 38352597›Full record

ArticlebioRxiv : the preprint server for biology2024

Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes.

Monique Mills, Chihiro Emori, Parveen Kumar, Zachary Boucher, Joshy George, Ewelina Bolcun-Filas

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Monique MillsThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.ORCID 0000-0001-6116-2837
Chihiro EmoriDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan.ORCID 0000-0001-8040-2517
Parveen KumarThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.ORCID 0000-0003-2739-273X
Zachary BoucherThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.ORCID 0000-0003-1814-1832
Joshy GeorgeThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.ORCID 0000-0001-8510-8229
Ewelina Bolcun-FilasThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.ORCID 0000-0003-4555-6670
Jackson Laboratory · USThe Graduate Center, CUNY · USThe University of Osaka · JP

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
NCI NIH HHS P30 CA034196
6 · The paper itself

Abstract

Immature oocytes enclosed in primordial follicles stored in female ovaries are under constant threat of DNA damage induced by endogenous and exogenous factors. Checkpoint kinase 2 (CHEK2) is a key mediator of the DNA damage response in all cells. Genetic studies have shown that CHEK2 and its downstream targets, p53 and TAp63, regulate primordial follicle elimination in response to DNA damage, however the mechanism leading to their demise is still poorly characterized. Single-cell and bulk RNA sequencing were used to determine the DNA damage response in wildtype and

Indexed as

CHEK2DNA Damage Responseoocyteovarysingle-cell transcriptomics

Identifiers

PMID38352597
PMCPMC10862846
OpenAlexW4391539964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.