Evidence map›Paper›PMID 38352567›Full record

ArticlebioRxiv : the preprint server for biology2024

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies.

Meggie Danielson, Chris J Nicolai, Thaomy T Vo, Natalie Wolf, Thomas P Burke

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Meggie DanielsonMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA USA.
Chris J NicolaiMolecular and Cell Biology, University of California, Berkeley, Berkeley, CA USA.
Thaomy T VoMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA USA.
Natalie WolfMolecular and Cell Biology, University of California, Berkeley, Berkeley, CA USA.
Thomas P BurkeMicrobiology and Molecular Genetics, University of California, Irvine, Irvine, CA USA.ORCID 0000-0002-1385-8757
University of California, Irvine · USUniversity of California, Berkeley · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Mechanisms of MHC-deficient tumor clearance using STING agonistsF31CA228381 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI NICOLAI, CHRISTOPHER JAMES · 2018 to 2019
$76k
NCI NIH HHS F31 CA228381NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

Bacterial pathogens that invade the eukaryotic cytosol are distinctive tools for fighting cancer, as they preferentially target tumors and can deliver cancer antigens to MHC-I. Cytosolic bacterial pathogens have undergone extensive preclinical development and human clinical trials, yet the molecular mechanisms by which they are detected by innate immunity in tumors is unclear. We report that intratumoral delivery of phylogenetically distinct cytosolic pathogens, including

Identifiers

PMID38352567
PMCPMC10862861
OpenAlexW4391466812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.