ArticlebioRxiv : the preprint server for biology2024
Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during
Tasia D Kellogg, Simona Ceglia, Benedikt M Mortzfeld, Abigail L Zeamer, Sage E Foley, Doyle V Ward, Shakti K Bhattarai, Beth A McCormick, Andrea Reboldi, Vanni Bucci
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 1 institution in 1 country.
Tasia D KelloggDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Simona CegliaImmunology and Microbial Pathogenesis Program, UMass Chan Medical School, Worcester, MA, USA.
Benedikt M MortzfeldDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-0563-8970 Abigail L ZeamerDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Sage E FoleyDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Doyle V WardDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4952-824X Shakti K BhattaraiDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Beth A McCormickDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.
Andrea ReboldiImmunology and Microbial Pathogenesis Program, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1137-6292 Vanni BucciDepartment of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3257-2922 University of Massachusetts Chan Medical School · US
Funding
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5MDevelopment of targeted microbiome therapeutics and dietary interventions for potent intestinal barrier promotion to minimize GI-ARSU01AI172987 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Vanni Bucci, Beth A McCormick · 2023 to 2026
$2.3MNIAID NIH HHS T32 AI007349NIAID NIH HHS U01 AI172987
6 · The paper itselfAbstract
Metabolic byproducts of the intestinal microbiota are crucial in maintaining host immune tone and shaping inter-species ecological dynamics. Among these metabolites, succinate is a driver of tuft cell (TC) differentiation and consequent type 2 immunity-dependent protection against invading parasites in the small intestine. Succinate is also a growth enhancer of the nosocomial pathogen
Indexed as
Clostridioides difficileDLCK1IL-25MicrobiomeSuccinateTuft CellsType 2 Immunity
Identifiers
PMID38352546
PMCPMC10862725
OpenAlexW4391450283
What OpenQuestion holds
Textmetadata
LicenceCC BY-ND
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