Evidence map›Paper›PMID 38352527›Full record

ArticlebioRxiv : the preprint server for biology2024

Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state.

Erin Neyhart, Na Zhou, Brandon R Munn, Robert G Law, Cameron Smith, Zakir H Mridha, Francisco A Blanco, Guochuan Li, Yulong Li, Matthew J McGinley and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Erin NeyhartNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9164-0553
Na ZhouNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7099-1351
Brandon R MunnBrain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.ORCID 0000-0002-3638-1605
Robert G LawNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-1220-3871
Cameron SmithNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-2079-4667
Zakir H MridhaNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9772-9812
Francisco A BlancoNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-1228-8625
Guochuan LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0002-9166-9919
Matthew J McGinleyNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-6516-9670
James M ShineBrain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia.ORCID 0000-0003-1762-5499
Jacob ReimerNeuroscience Department, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-4364-8846
Baylor College of Medicine · USPeking University · CNThe University of Sydney · AU

Funding

Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Elucidating neural circuits and pupil readouts of motivated effortful listeningR01DC017797 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI MCGINLEY, MATTHEW J · 2019 to 2023
$2.4M
The Spatial and Temporal Scale of Neuromodulation in Mouse Sensory CortexRF1NS128901 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI REIMER, JACOB · 2022 to 2022
$2.3M
Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
Validation and Optimization of Two-Photon Dendritic Voltage Imaging in VivoR34NS132045 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI REIMER, JACOB · 2023 to 2024
$672k
Neuromodulatory mechanisms of listening effortR03DC015618 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI MCGINLEY, MATTHEW J · 2016 to 2018
$476k
Determining the role of cortical acetylcholine in fast waking state transitionsF31NS122428 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NEYHART, ERIN · 2021 to 2023
$140k
Noradrenergic gating of astrocyte calcium-mediated homeostasis in vivoF31NS132465 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SMITH, CAMERON LEWIS · 2023 to 2023
$48k
NIDCD NIH HHS R01 DC017797NIDCD NIH HHS R03 DC015618NINDS NIH HHS F31 NS122428NINDS NIH HHS F31 NS132465NINDS NIH HHS R34 NS132045NINDS NIH HHS RF1 NS128901NINDS NIH HHS U01 NS103558NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS120824
6 · The paper itself

Abstract

Even under spontaneous conditions and in the absence of changing environmental demands, awake animals alternate between increased or decreased periods of alertness. These changes in brain state can occur rapidly, on a timescale of seconds, and neuromodulators such as acetylcholine (ACh) are thought to play an important role in driving these spontaneous state transitions. Here, we perform the first simultaneous imaging of ACh sensors and GCaMP-expressing axons

Identifiers

PMID38352527
PMCPMC10862699
OpenAlexW4388743958

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.