Evidence map›Paper›PMID 38352521›Full record

ArticlebioRxiv : the preprint server for biology2024

Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection.

Zhiyu Zang, Chengqian Zhang, Kyoung Jin Park, Daniel A Schwartz, Ram Podicheti, Jay T Lennon, Joseph P Gerdt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhiyu ZangDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-4879-7077
Chengqian ZhangDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Kyoung Jin ParkDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Daniel A SchwartzDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Ram PodichetiCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-3449-5155
Jay T LennonDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-3126-6111
Joseph P GerdtDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-0375-4110
Indiana University Bloomington · US

Funding

NRSA Training CoreTL1TR002531 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI FOTI, DANIEL JUSTIN, HURLEY, THOMAS D. · 2018 to 2022
$2.5M
NCATS NIH HHS TL1 TR002531
6 · The paper itself

Abstract

To overtake competitors, microbes produce and secrete secondary metabolites that kill neighboring cells and sequester nutrients. This natural product-mediated competition likely evolved in complex microbial communities that included viral pathogens. From this ecological context, we hypothesized that microbes secrete metabolites that "weaponize" natural pathogens (i.e., bacteriophages) to lyse their competitors. Indeed, we discovered a bacterial secondary metabolite that sensitizes other bacteria to phage infection. We found that this metabolite provides the producer (a

Identifiers

PMID38352521
PMCPMC10862869
OpenAlexW4391444833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.