Evidence map›Paper›PMID 38352410›Full record

ArticlebioRxiv : the preprint server for biology2024

Casey Griffin, Kelsey Coppenrath, Doha Khan, Ziyan Lin, Marko Horb, Jean-Pierre Saint-Jeannet

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Casey GriffinDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, USA.
Kelsey CoppenrathEugene Bell Center for Regenerative Biology and Tissue Engineering and National Xenopus Resource, Marine Biological Laboratory, Woods Hole, Massachusetts, USA.
Doha KhanDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, USA.
Ziyan LinApplied Bioinformatics Laboratory, NYU Grossman School of Medicine, New York, NY, USA.
Marko HorbEugene Bell Center for Regenerative Biology and Tissue Engineering and National Xenopus Resource, Marine Biological Laboratory, Woods Hole, Massachusetts, USA.
Jean-Pierre Saint-JeannetDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, USA.
New York University · USMarine Biological Laboratory · US

Funding

Resource CoreP40OD010997 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2012 to 2026
$13.1M
Xenopus Mutant ResourceR24OD030008 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2020 to 2026
$6.0M
Pathogenesis of craniofacial defects in Nager syndromeR01DE025468 · NIDCR · NEW YORK UNIVERSITY · PI SAINT-JEANNET, JEAN-PIERRE · 2016 to 2020
$2.0M
Deciphering the underlying mechanisms of craniofacial spliceosomopathiesK99DE034476 · NIDCR · NEW YORK UNIVERSITY · PI GRIFFIN, CASEY · 2024 to 2025
$251k
Function of SF3B4 in neural crest developmentF32DE030699 · NIDCR · NEW YORK UNIVERSITY · PI GRIFFIN, CASEY · 2021 to 2023
$212k
NIDCR NIH HHS F32 DE030699NIDCR NIH HHS K99 DE034476NIDCR NIH HHS R01 DE025468NIH HHS P40 OD010997NIH HHS R24 OD030008
6 · The paper itself

Abstract

Nager syndrome is a rare craniofacial and limb disorder characterized by midface retrusion, micrognathia, absent thumbs, and radial hypoplasia. This disorder results from haploinsufficiency of SF3B4 (splicing factor 3b, subunit 4) a component of the pre-mRNA spliceosomal machinery. The spliceosome is a complex of RNA and proteins that function together to remove introns and join exons from transcribed pre-mRNA. While the spliceosome is present and functions in all cells of the body, most spliceosomopathies - including Nager syndrome - are cell/tissue-specific in their pathology. In Nager syndrome patients, it is the neural crest (NC)-derived craniofacial skeletal structures that are primarily affected. To understand the pathomechanism underlying this condition, we generated a

Indexed as

apoptosisNager syndromeneural crestSF3B4splicingXenopus tropicalis

Identifiers

PMID38352410
PMCPMC10862923
OpenAlexW4391465629

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.