Evidence map›Paper›PMID 38352384›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine.

Emily S Ford, Alvason Li, Kerry J Laing, Lichun Dong, Kurt Diem, Lichen Jing, Krithi Basu, Mariliis Ott, Jim Tartaglia, Sanjay Gurunathan and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Emily S FordVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Alvason LiVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Kerry J LaingDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA.
Lichun DongDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA.
Kurt DiemDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle WA.
Lichen JingDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA.
Krithi BasuDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA.
Mariliis OttDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle WA.
Jim TartagliaSanofi Pasteur, Swiftwater PA.
Sanjay GurunathanSanofi Pasteur, Swiftwater PA.
Jack L ReidClinical Research Division, Fred Hutch Cancer Center, Seattle WA.
Matyas EcsediClinical Research Division, Fred Hutch Cancer Center, Seattle WA.
Aude G ChapuisClinical Research Division, Fred Hutch Cancer Center, Seattle WA.
Meei-Li HuangDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle WA.
Amalia S MagaretVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Christine JohnstonVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Jia ZhuVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
David M KoelleVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Lawrence CoreyVaccine and Infectious Diseases Division, Fred Hutch Cancer Center, Seattle WA.
Infectious Disease Research Institute · USUniversity of Washington · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZASanofi (United States) · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 1991 to 2017
$34.3M
Understand & overcome resistance to PD-1P01CA225517 · NCI · UNIVERSITY OF WASHINGTON · PI PAUL NGHIEM · 2019 to 2026
$22.7M
Urethral microbiome and non-gonococcal urethritis in men who have sex with men (MU19AI113173 · NIAID · UNIVERSITY OF WASHINGTON · PI MARRAZZO, JEANNE M · 2014 to 2018
$14.3M
Harnessing Tissue Resident Memory T Cells for Immunotherapy of Herpes Virus InfectionsR01AI134878 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE · 2018 to 2022
$3.4M
Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusionR01AI143773 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2024
$2.7M
CYTOTOXIC T CELL RESPONSES TO HSV IN HIV INFECTIONR01AI042528 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE, ZHU, JIA · 1998 to 2016
$2.7M
HSV-2 specificity and phenotyping of tissue-based T cells in genital skin biopsies of HSV-2 reactivationK08AI148588 · NIAID · UNIVERSITY OF WASHINGTON · PI FORD, EMILY · 2020 to 2024
$947k
NCI NIH HHS P01 CA225517NCI NIH HHS P30 CA015704NIAID NIH HHS K08 AI148588NIAID NIH HHS P01 AI030731NIAID NIH HHS R01 AI042528NIAID NIH HHS R01 AI134878NIAID NIH HHS R01 AI143773NIAID NIH HHS U19 AI113173
6 · The paper itself

Abstract

The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4

Identifiers

PMID38352384
PMCPMC10863019
OpenAlexW4210683568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.