Evidence map›Paper›PMID 38352369›Full record

ArticlebioRxiv : the preprint server for biology2025

Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in the developing cochlea.

Jihyun Kim, Edward Martinez, Jingyun Qiu, Julie Zhouli Ni, Kelvin Y Kwan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 3 countries.

Jihyun KimKeck Center for Collaborative Neuroscience and Stem Cell Research Center, Rutgers University, Piscataway, NJ 08854, USA.
Edward MartinezKeck Center for Collaborative Neuroscience and Stem Cell Research Center, Rutgers University, Piscataway, NJ 08854, USA.
Jingyun QiuDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Julie Zhouli NiDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Kelvin Y KwanKeck Center for Collaborative Neuroscience and Stem Cell Research Center, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-8617-5543
Rutgers, The State University of New Jersey · US

Funding

The role of transcription factors and chromatin remodeling proteins in spiral ganglion neuron regenerationR01DC015000 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y. · 2016 to 2020
$2.0M
Epigenetic mechanisms of cochlear damage and repairR01DC022483 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI Kelvin Y. Kwan · 2025 to 2026
$1.3M
NIDCD NIH HHS R01 DC015000NIDCD NIH HHS R01 DC022483
6 · The paper itself

Abstract

Spiral ganglion neurons (SGNs) are the primary afferent neurons that convey sound information from the cochlea, but the epigenetic changes that occur during development are unknown. We identified the chromodomain helicase binding protein 4 (CHD4) expression in SGNs. CHD4 is an ATP-dependent chromatin remodeler. We employed the

Indexed as

axon guidanceCHD4chromatin remodelingepigeneticsspiral ganglion neurons

Identifiers

PMID38352369
PMCPMC10862897
OpenAlexW4391554624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.