Evidence map›Paper›PMID 38352349›Full record

ArticlebioRxiv : the preprint server for biology2024

Focused Ultrasound Blood-Brain Barrier Opening Arrests the Growth and Formation of Cerebral Cavernous Malformations.

Delaney G Fisher, Khadijeh A Sharifi, Ishaan M Shah, Catherine M Gorick, Victoria R Breza, Anna C Debski, Matthew R Hoch, Tanya Cruz, Joshua D Samuels, Jason P Sheehan and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Delaney G FisherDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.ORCID 0000-0002-1876-4733
Khadijeh A SharifiDepartment of Neuroscience, University of Virginia, Charlottesville, VA.
Ishaan M ShahDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Catherine M GorickDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.ORCID 0000-0002-0139-3438
Victoria R BrezaDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.ORCID 0000-0003-2294-7222
Anna C DebskiDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Matthew R HochDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Tanya CruzDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Joshua D SamuelsDepartment of Neuroscience, University of Virginia, Charlottesville, VA.
Jason P SheehanDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA.
David SchlesingerDepartment of Radiation Oncology, University of Virginia Health System, Charlottesville, VA.
David MooreFocused Ultrasound Foundation, Charlottesville, VA.
John R LukensDepartment of Neuroscience, University of Virginia, Charlottesville, VA.
G Wilson MillerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Petr TvrdikDepartment of Neuroscience, University of Virginia, Charlottesville, VA.
Richard J PriceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.ORCID 0000-0002-0237-2102
University of Virginia · USUniversity of Virginia Health System · USFocused Ultrasound Foundation · US

Funding

Genome Editing the Blood-Brain Barrier with Sonoselective Focused UltrasoundR01EB030744 · NIBIB · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2021 to 2024
$2.4M
Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomasR01EB030409 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2021 to 2024
$2.3M
Toward precision radiotherapy: Physiological modeling of respiratory motion based on ultra-quality 4D-MRIR01CA226899 · NCI · UNIVERSITY OF VIRGINIA · PI CAI, JING, MILLER, G. WILSON · 2019 to 2023
$2.2M
MR Image-Guided Drug Delivery to Cerebral Cavernous Malformations with Focused UltrasoundR01CA279134 · NCI · UNIVERSITY OF VIRGINIA · PI Richard J. Price · 2024 to 2026
$1.8M
Role of Microglial Calcium Waves in Ischemic StrokeR21NS116431 · NINDS · UNIVERSITY OF VIRGINIA · PI TVRDIK, PETR · 2021 to 2022
$444k
ImmunoPET Assessment of anti-CD47 Immunotherapy Delivery to Glioblastoma with Focused UltrasoundR21NS118278 · NINDS · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2020 to 2020
$420k
American Heart Association-American Stroke Association 830909NCI NIH HHS R01 CA226899NCI NIH HHS R01 CA279134NIBIB NIH HHS R01 EB030409NIBIB NIH HHS R01 EB030744NINDS NIH HHS R21 NS116431NINDS NIH HHS R21 NS118278
6 · The paper itself

Abstract

backgroundCerebral cavernous malformations (CCM) are vascular lesions within the central nervous system, consisting of dilated and hemorrhage-prone capillaries. CCMs can cause debilitating neurological symptoms, and surgical excision or stereotactic radiosurgery are the only current treatment options. Meanwhile, transient blood-brain barrier opening (BBBO) with focused ultrasound (FUS) and microbubbles is now understood to exert potentially beneficial bioeffects, such as stimulation of neurogenesis and clearance of amyloid-β. Here, we tested whether FUS BBBO could be deployed therapeutically to control CCM formation and progression in a clinically-representative murine model.

methodsCCMs were induced in mice by postnatal, endothelial-specific

resultsFUS BBBO elicited gadolinium accumulation primarily at the perilesional boundaries of CCMs, rather than lesion cores. Passive cavitation detection and gadolinium contrast enhancement were comparable in CCM and wild-type mice, indicating that

conclusionsOur results establish FUS BBBO as a novel, non-invasive modality that can safely arrest murine CCM growth and prevent their

Identifiers

PMID38352349
PMCPMC10862920
OpenAlexW4391537540

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.