Evidence map›Paper›PMID 38352301›Full record

ArticlebioRxiv : the preprint server for biology2024

The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription.

Katharine Umphred-Wilson, Shashikala Ratnayake, Qianzi Tang, Rui Wang, Ballachanda N Devaiah, Lan Zhou, Qingrong Chen, Daoud Meerzaman, Dinah S Singer, Stanley Adoro

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katharine Umphred-WilsonExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-6416-0466
Shashikala RatnayakeComputational Genomics and Bioinformatics Branch, Center for Biomedical Informatics & Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850.
Qianzi TangCollege of Animal Science and Technology, Sichuan Agricultural University; Chengdu 611130, China.
Rui WangCollege of Animal Science and Technology, Sichuan Agricultural University; Chengdu 611130, China.
Ballachanda N DevaiahExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Lan ZhouDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030.
Qingrong ChenComputational Genomics and Bioinformatics Branch, Center for Biomedical Informatics & Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850.
Daoud MeerzamanComputational Genomics and Bioinformatics Branch, Center for Biomedical Informatics & Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850.
Dinah S SingerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Stanley AdoroExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
National Institutes of Health · USSichuan Agricultural University · CNMethodist Hospital · US

Funding

GRADUATE TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM008056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DIEHL, JOHN ALAN, SNIDER, MARTIN D · 1985 to 2019
$7.1M
Targeting Notch2 in Hematopoietic Cell Therapy.R01HL103827 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ZHOU, LAN · 2012 to 2022
$4.3M
Proteostasis regulators in blood cell development and functionZIABC012135 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ADORO, STANLEY · 2023 to 2025
$3.1M
Mechanisms of tunable posttranslational control of T-cell homeostasis and toleranceR01AI143992 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI XIAO, TSAN SAM · 2019 to 2023
$2.2M
Hes1-loss promotes dysregulation of epithelial homeostasis and inflammation in a serrated adenocarcinoma modelR01CA222064 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ZHOU, LAN · 2018 to 2022
$2.0M
Regulation of BRD4 FunctionZIABC012146 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, DINAH S. · 2023 to 2025
$881k
Probing the role of the IRE1alpha-XBP1 pathway in normal and malignant hematopoiesisK22CA218467 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ADORO, STANLEY · 2017 to 2018
$385k
Intramural NIH HHS ZIA BC012135NCI NIH HHS K22 CA218467NCI NIH HHS R01 CA222064NHLBI NIH HHS R01 HL103827NIAID NIH HHS R01 AI143992NIGMS NIH HHS T32 GM008056
6 · The paper itself

Abstract

Oncogene activity rewires cellular transcription, creating new transcription networks to which cancer cells become addicted, by mechanisms that are still poorly understood. Using human and mouse models of T cell acute lymphoblastic leukemia (T-ALL), we identify an essential nuclear role for CHMP5, a cytoplasmic endosomal sorting complex required for transport (ESCRT) protein, in establishing and maintaining the T-ALL transcriptional program. Nuclear CHMP5 promoted the T-ALL gene program by augmenting recruitment of the co-activator BRD4 by the histone acetyl transferase p300 selectively at enhancers and super-enhancers, an interaction that potentiated H3K27 acetylation at these regulatory enhancers. Consequently, loss of CHMP5 diminished BRD4 occupancy at enhancers and super-enhancers and impaired RNA polymerase II pause release, which resulted in downregulation of key T-ALL genes, notably

Identifiers

PMID38352301
PMCPMC10862731
OpenAlexW4391517741

What OpenQuestion holds

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LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.