Evidence map›Paper›PMID 38352105›Full record

ArticleCureus2024

Analgesic Effect of the Kampo Formula Yokukansan via the Suppression of Substance P in an Experimental Rat Model of Hunner-Type Interstitial Cystitis.

Yoshiki Tsunokawa, Mana Tsukada, Tatsuki Inoue, Masashi Tamaoka, Toshiki Mugita, Oyunchimeg Chuluunbat, Yoshiko Maeda, Takashi Fukagai, Yoshio Ogawa, Masataka Sunagawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yoshiki TsunokawaDepartment of Physiology, Showa University Graduate School of Medicine, Tokyo, JPN.
Mana TsukadaResearch Administration Center, Showa University, Tokyo, JPN.
Tatsuki InoueDepartment of Urology, Showa University School of Medicine, Tokyo, JPN.
Masashi TamaokaDepartment of Physiology, Showa University Graduate School of Medicine, Tokyo, JPN.
Toshiki MugitaDepartment of Physiology, Showa University Graduate School of Medicine, Tokyo, JPN.
Oyunchimeg ChuluunbatDepartment of Physiology, Showa University Graduate School of Medicine, Tokyo, JPN.
Yoshiko MaedaDepartment of Urology, Showa University School of Medicine, Tokyo, JPN.
Takashi FukagaiDepartment of Urology, Showa University School of Medicine, Tokyo, JPN.
Yoshio OgawaDepartment of Urology, Showa University School of Medicine, Tokyo, JPN.
Masataka SunagawaDepartment of Physiology, Showa University Graduate School of Medicine, Tokyo, JPN.
Showa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionYokukansan (YKS), a Kampo formula used in traditional Japanese medicine, has an analgesic effect, and is used for various pain disorders. This study investigated its analgesic effects on Hunner-type interstitial cystitis (HIC) and its mechanism of action in animal models.   Methods: Rats with toll-like receptor-7 agonist (loxoribine)-induced HIC were used. Eight-week-old female Wistar rats were divided into three groups: control, HIC, and HIC-administered YKS (YKS + HIC). Bladder pain was assessed based on escape behavior using the von Frey test. Three days after HIC induction, the bladder and spinal cord were excised, and the expression of substance P (SP) was examined.   Results: The pain threshold decreased significantly in the HIC group compared to that in the control group, but this decrease was suppressed by further YKS administration. The expression of SP in the bladder wall and spinal cord increased significantly in the HIC group compared to that in the control group; however, this increase was suppressed by YKS administration.

conclusionSP is involved in the onset of bladder pain via neurokinin 1 receptors in bladder tissue. YKS may be useful for managing HIC-induced pain, and the suppression of SP secretion is one of its mechanisms of action.

Indexed as

analgesic effecthunner-type interstitial cystitiskampo formulasubstance pyokukansan

Identifiers

PMID38352105
PMCPMC10862183
OpenAlexW4390858835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.