Evidence map›Paper›PMID 38351964›Full record

ArticleCureus2023

Impact of miR-155 rs767649 Polymorphism on Rheumatoid Arthritis Activity in Egyptian Patients.

Mohamed A Elghouneimy, Marwa A Ramadan, Enas A Farrag, Hanan F Ibrahim, Seham K Khirala, Nora Seliem, Sammar A Kasim, Eman M Moazen, Asmaa A Attia, Faten I Mohammed and 1 more

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In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Mohamed A ElghouneimyPlastic Surgery, Nile Insurance Hospital, Cairo, EGY.
Marwa A RamadanClinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Enas A FarragClinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Hanan F IbrahimMedical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Seham K KhiralaMedical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Nora SeliemBiochemistry Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Sammar A KasimInternal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Eman M MoazenDepartment of Chest Disease, Faculty of Medicine, Al-Azhar University, Cairo, EGY.
Asmaa A AttiaInternal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Faten I MohammedPhysiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Aya A GhamryMedical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
National Health Insurance Service · KRAl Azhar University · QAAl-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic inflammatory condition that impacts not only the musculoskeletal system but also various other systems in the body, including the cutaneous, ocular, respiratory, cardiovascular, and circulatory systems. MicroRNAs (miRNAs) are a class of naturally occurring and highly conserved transcripts that primarily function in the regulation of gene expression. They accomplish this by facilitating the degradation of messenger RNA (mRNA) or by repressing mRNA translation. miRNAs are well-known regulators of a variety of cellular processes. Therefore, we aimed to detect the impact of miR-155 rs767649 polymorphism on RA activity.

methodsThis case-control study included 66 Egyptian patients with RA who visited Al-Zhraa University Hospital, Internal Medicine Department, Cairo, Egypt, and 50 apparently healthy control subjects matched for age and sex. The participants were subjected to full clinical evaluation, including assessments of the disease activity score (DAS), erythrocyte sedimentation rate (ESR), liver and kidney function, anti-cyclic citrullinated peptide antibody (anti-CCP), and miR-155 polymorphism using real-time polymerase chain reaction (PCR).

resultsIn the RA group, the majority (98.5%) were female, with a mean age of 43 years, while in the control group, 94% were female, with a mean age of 43.4 years. Comparison of laboratory parameters indicated significantly lower hemoglobin levels, higher ESR, and higher serum creatinine and anti-CCP levels in the RA group than in the control group. The RA group had a significantly higher frequency of TT genotypes and significantly lower frequencies of TA and TT genotypes than the control group. Considering the TT genotype and T allele as references, TA, AA, and TA/AA genotypes in the dominant model; AA in the recessive model; and A allele were significantly associated with protective effects against RA development (p<0.05, odds ratio<1).

conclusionrs767649, the functional variant of miR-155, plays an important role in susceptibility to the increased risk of RA, suggesting that miR-155 can be used as a therapeutic target for the treatment of Egyptian patients with RA.

Indexed as

disease activitymicrornamir-155rheumatoid arthritisrs767649

Identifiers

PMID38351964
PMCPMC10862083
OpenAlexW4388940987

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.