Evidence map›Paper›PMID 38351927›Full record

ArticleArXiv2024

Proton Pencil-Beam Scanning Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG.

Wei Liu, Hongying Feng, Paige A Taylor, Minglei Kang, Jiajian Shen, Jatinder Saini, Jun Zhou, Huan B Giap, Nathan Y Yu, Terence S Sio and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Wei LiuDepartment of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Hongying FengDepartment of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Paige A TaylorThe Imaging and Radiation Oncology Core Houston Quality Assurance Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Minglei KangNew York Proton Center, New York City, New York, USA.
Jiajian ShenDepartment of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Jatinder SainiSeattle Cancer Care Alliance Proton Therapy Center and Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Jun ZhouDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia.
Huan B GiapDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina, USA.
Nathan Y YuDepartment of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Terence S SioDepartment of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Pranshu MohindraDepartment of Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Joe Y ChangDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston.
Jeffrey D BradleyDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ying XiaoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Charles B SimoneNew York Proton Center, New York City, New York, USA.
Liyong LinDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia.
WinnMed · USEmory University · USNew York Proton Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Pennsylvania · USChina Three Gorges University · CNMedical University of South Carolina · USSeattle Cancer Care Alliance · USUniversity Hospitals of Cleveland · US

Funding

4D Robust Optimization in Intensity-Modulated Proton TherapyK25CA168984 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIU, WEI · 2012 to 2015
$450k
NCI NIH HHS K25 CA168984
6 · The paper itself

Abstract

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical organ sparing from both PBSPT and SBRT, this new delivery technique has great potential to improve the therapeutic ratio, particularly for tumors near critical organs. Safe and effective implementation of PBSPT SBRT/hypofractionation to treat thoracic malignancies is more challenging than the conventionally-fractionated PBSPT due to concerns of amplified uncertainties at the larger dose per fraction. NRG Oncology and Particle Therapy Cooperative Group (PTCOG) Thoracic Subcommittee surveyed US proton centers to identify practice patterns of thoracic PBSPT SBRT/hypofractionation. From these patterns, we present recommendations for future technical development of proton SBRT/hypofractionation for thoracic treatment. Amongst other points, the recommendations highlight the need for volumetric image guidance and multiple CT-based robust optimization and robustness tools to minimize further the impact of uncertainties associated with respiratory motion. Advances in direct motion analysis techniques are urgently needed to supplement current motion management techniques.

Identifiers

PMID38351927
PMCPMC10862926
OpenAlexW4392059363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.