Synthesis, Antimicrobial Evaluation, and Interaction of Emodin Alkyl Azoles with DNA and HSA.

Yu-Hang Zhou, Ying Wang, Hui-Zhen Zhang

Abstract read

In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.0field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yu-Hang ZhouSchool of Medicine, Linyi University, Linyi 276000, China.

Ying WangSchool of Medicine, Linyi University, Linyi 276000, China.

Hui-Zhen ZhangSchool of Medicine, Linyi University, Linyi 276000, China.ORCID 0000-0003-4434-9493

Linyi University · CN

Funding

2022 COVID-19 Prevention and Control Science and Technology Research Project of Linyi City 2022XGWZ007Doctoral Scientific Research Foundation of Linyi University LYDX2016BS030Key Research and Development project of Shandong Province 2019GSF108216Project of Linyi Agriculture and Rural Bureau HX150013Shandong Provincial Natural Science Foundation ZR2020QB167

6 · The paper itself

Abstract

objectiveThis study aimed to overcome the growing antibiotic resistance. Moreover, the new series of emodin alkyl azoles were synthesized.

methodThe novel emodin alkyl azoles were synthesized using commercial emodin and azoles by alkylation. The NMR and HRMS spectra were employed to confirm the structures of novel prepared compounds. The

resultsThe

conclusionThis work may supply useful directions for the exploration of novel antimicrobial agents.

Indexed as

AzolesEmodinMicrobial Sensitivity TestsMolecular Docking SimulationSerum Albumin, HumanStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsDNADNA, BacterialEscherichia coliHumansMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAzolesDNADNA, BacterialEmodinSerum Albumin, HumanantibacterialantifungalazoleDNAEmodinHSA.

Identifiers

PMID38351695

DOI10.1016/j.bmcl.2013.11.013

OpenAlexW4391820599

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.