Evidence map›Paper›PMID 38351554›Full record

ReviewCancer reports (Hoboken, N.J.)2024

Abscopal effect in maxillary sinus cancer: Insights from two case reports and a literature review.

Akihiro Sakai, Koji Ebisumoto, Hiroaki Iijima, Mayu Yamauchi, Daisuke Maki, Tsuyoshi Fukuzawa, Kenji Okami

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Akihiro SakaiDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.ORCID 0000-0002-1068-5061
Koji EbisumotoDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.
Hiroaki IijimaDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.ORCID 0000-0002-3343-9111
Mayu YamauchiDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.
Daisuke MakiDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.ORCID 0000-0003-2743-6958
Tsuyoshi FukuzawaDepartment of Radiation Oncology, Tokai University, School of Medicine, Isehara, Japan.
Kenji OkamiDepartment of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.ORCID 0000-0003-4228-3347
Tokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe abscopal effect is a rare phenomenon in which localized radiation therapy triggers tumor reduction in nontargeted areas. Although this phenomenon has been observed in various cancer types, it remains infrequent and not fully understood. CASE: Two patients with maxillary sinus cancer with distant metastases were treated with radiotherapy after immune checkpoint inhibitor (ICI) therapy. The patients demonstrated abscopal effects following ICI therapy and radiotherapy, showing shrinkage in metastatic areas not directly targeted by radiation.

conclusionThis report was reviewed to examine the synergistic effects of ICI and radiotherapy and to identify optimal strategies to enhance the abscopal effect in clinical practice. It has also touched on various ongoing debates and clinical trials aimed at understanding and exploiting this effect to improve cancer treatment. The exact mechanisms and optimal treatment protocols remain areas for future research.

Indexed as

Maxillary Sinus NeoplasmsCombined Modality TherapyHumansImmunotherapyabscopal effecthead and neck cancerimmune checkpoint inhibitorsmaxillary sinus cancer

Identifiers

PMID38351554
PMCPMC10864721
OpenAlexW4391817848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.