ArticleNature genetics2024
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Erratum issuedOpen access · hybridAbstract read
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Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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40citing papers in PubMed
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40 citing papers in PubMed, 49 citations in OpenAlex.
- Establishment, biobanking, and multi-omics characterization of 41 patient-derived colorectal cancer organoids: MYC/PRC classification.Translational oncology · 2026Article
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- Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state.Communications biology · 2026Article
- Deep learning-based H&E-derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response.The Journal of pathology · 2026Article
- Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.iScience · 2026Article
- Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes.Molecular systems biology · 2026Article
- MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance.Nature · 2026Article
- Advances in Colorectal Cancer Cell Biology and Clonal Evolution.International journal of molecular sciences · 2026Review
- Integrative analysis of transcriptomic data reveals a predictive gene signature for chemoradiotherapy response in rectal cancer.iScience · 2026Article
- Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Molecular mosaic of colorectal cancer: Why one classification system is no longer enough?World journal of gastrointestinal oncology · 2026Article
- Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation.Frontiers in oncology · 2026Review
- Pathway-based molecular subtyping identifies LAMP5 as an EMT-associated prognostic target in colorectal cancer.Frontiers in pharmacology · 2026Article
- Tumor Imaging Heterogeneity Index-Inspired Insights into the Unveiling Tumor Microenvironment of Breast Cancer.International journal of molecular sciences · 2025Article
- Consensus Molecular Subtypes (CMS) Classification: a progress towards Subtype-Driven treatments in colorectal cancer.World journal of surgical oncology · 2025Review
- Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell-Mediated Immunomodulation.Cancer research · 2025Article
- Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer.Journal of translational medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
44 authors at 9 institutions in 4 countries.
Sudhir B MallaThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0001-5862-3815
Ryan M Byrne *The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0001-6505-6345
Maxime W Lafarge *Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Shania M CorryThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Natalie C FisherThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-1769-7468
Petros K TsantoulisFaculty of Medicine, Université de Genève, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-3613-6682
Megan L MillsCancer Research UK Scotland Institute, Glasgow, UK.
Rachel A RidgwayCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-0198-8244
Tamsin R M LannaganCancer Research UK Scotland Institute, Glasgow, UK.
Arafath K NajumudeenCancer Research UK Scotland Institute, Glasgow, UK.
Kathryn L GilroyCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-4607-194X
Raheleh AmirkhahThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-3494-271X
Sarah L MaguireThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0001-6654-3620
Eoghan J MulhollandCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1200-9825
Hayley L Belnoue-DavisCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2914-4932
Elena GrassiCandiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.ORCID http://orcid.org/0000-0003-1066-927X
Marco VivianiCandiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.ORCID http://orcid.org/0000-0003-4698-8870
Emily RoganThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Keara L RedmondThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Svetlana SakhnevychThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Aoife J McCooeyThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Courtney BullThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Emily HoeyThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Nicoleta SineviciThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Holly HallCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-2779-2565
Baharak AhmaderaghiSchool of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-4166-6290
Enric DomingoDepartment of Oncology, University of Oxford, Oxford, Oxfordshire, UK.ORCID http://orcid.org/0000-0003-4390-8767
Andrew BlakeDepartment of Oncology, University of Oxford, Oxford, Oxfordshire, UK.
Susan D RichmanLeeds Institute of Medical Research, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-3993-5041
Claudio IsellaCandiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.
Crispin MillerCancer Research UK Scotland Institute, Glasgow, UK.
Andrea BertottiCandiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.
Livio TrusolinoCandiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.ORCID http://orcid.org/0000-0002-6379-3365
Maurice B LoughreyThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Emma M KerrThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-1952-4213
Sabine TejparDepartment of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3281-8643
S:CORT consortium
Timothy S MaughanDepartment of Oncology, University of Oxford, Oxford, Oxfordshire, UK.
Mark LawlerThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Andrew D CampbellCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-3930-1276
Simon J LeedhamCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1476-6982
Viktor H KoelzerDepartment of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-9206-4885
Owen J SansomCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0001-9540-3010
Philip D DunneThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. p.dunne@qub.ac.uk.ORCID http://orcid.org/0000-0001-9160-283X
Queen's University Belfast · GBCancer Research UK · GBCandiolo Cancer Institute · ITCentre for Human Genetics · GBUniversity of Oxford · GBUniversity of Zurich · CHKU Leuven · BEUniversity of Geneva · CHUniversity of Leeds · GB
Funding
Cancer Research UK 26045Cancer Research UK 29801Cancer Research UK 29834Medical Research Council MC_PC_21042Medical Research Council MR/M016587/1Wellcome Trust 206314/Z/17/Z
Abstract
Molecular stratification using gene-level transcriptional data has identified subtypes with distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular subtypes (CMS) in colorectal cancer (CRC). Here, rather than gene-level data, we make use of gene ontology and biological activation state information for initial molecular class discovery. In doing so, we defined three pathway-derived subtypes (PDS) in CRC: PDS1 tumors, which are canonical/LGR5
Indexed as
Colorectal NeoplasmsBiomarkers, TumorCell DifferentiationGene Expression ProfilingHumansPhenotypePrognosisBiomarkers, Tumor
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.