Evidence map›Paper›PMID 38351380›Full record

ArticleNature chemistry2024

Biocatalytic strategy for the construction of sp

David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, K N Houk, Rudi Fasan

Open access · greenAbstract read
In one paragraph

Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

David A Vargas *Process Research and Development, Merck, Rahway, NJ, USA.ORCID 0000-0002-6997-911X
Xinkun Ren *College of Engineering and Applied Sciences, Nanjing University, Nanjing, China.
Arkajyoti Sengupta *Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.ORCID 0000-0002-9917-2472
Ledong ZhuEnvironment Research Institute, Shandong University, Qingdao, People's Republic of China.
Satyajit RoyDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0001-7374-4797
Marc Garcia-BorràsInstitut de Química Computacional i Catàlisi (IQCC), Departament de Química, Universitat de Girona, Girona, Spain.ORCID 0000-0001-9458-1114
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA. houk@chem.ucla.edu.ORCID 0000-0002-8387-5261
Rudi FasanDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX, USA. rudi.fasan@utdallas.edu.ORCID 0000-0003-4636-9578
The University of Texas at Dallas · USUniversity of California, Los Angeles · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNanjing University · CNShandong University · CNUniversitat de Girona · ES

Funding

Research Training in Complementary and Integrative MedicineT32AT000051 · NCCIH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GLORIA Y YEH · 1999 to 2026
$10.2M
Selective P450 Oxidation Catalysts for Synthesis of Bioactive MoleculesR01GM098628 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI FASAN, RUDI · 2012 to 2024
$4.7M
Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF/TOF) Mass SpectrometerS10OD030302 · OD · UNIVERSITY OF ROCHESTER · PI NILSSON, BRADLEY L. · 2021 to 2021
$304k
GINSENG'S EFFECTS ON MRNA PROFILES IN A DIABETES-2 MODELF32AT000051 · NCCIH · UNIVERSITY OF TEXAS AUSTIN · PI PAN, SHUJIA J · 1999 to 2001
$96k
NCCIH NIH HHS F32 AT000051NCCIH NIH HHS T32 AT000051NIGMS NIH HHS R01 GM098628NIH HHS S10 OD030302
6 · The paper itself

Abstract

Catalysis with engineered enzymes has provided more efficient routes for the production of active pharmaceutical agents. However, the potential of biocatalysis to assist in early-stage drug discovery campaigns remains largely untapped. In this study, we have developed a biocatalytic strategy for the construction of sp

Indexed as

BiocatalysisPolycyclic CompoundsCyclizationDirected Molecular EvolutionModels, MolecularStereoisomerismThiophenesbenzothiophenePolycyclic CompoundsThiophenes

Identifiers

PMID38351380
PMCPMC11088497
OpenAlexW4391779739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.