ArticleScientific reports2024
Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Divergent behavioral strategies in Wistar and Wistar-Kyoto rats in a naturalistic task reveal mood disorder phenotypes.iScience · 2026Article
- Conjoint influence of effort and delay in decision making and its implication for the neural mechanisms of choice.Cognitive, affective & behavioral neuroscience · 2026Article
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- The impact of long-term isolation on anxiety, depressive-like and social behavior in aging Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) male rats.Scientific reports · 2024Article
- Evaluation of New Approaches to Depression Treatment Using an Animal Model of Pharmacoresistant Depression.International journal of molecular sciences · 2024Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Major depressive disorder is a common psychiatric condition often resistant to medication. The Wistar-Kyoto (WKY) rat has been suggested as an animal model of depression; however, it is still challenging to translate results from animal models into humans. Solitary housing is a mild stress paradigm that can simulate the environment of depressive patients with limited social activity due to symptoms. We used voxel-based morphometry to associate the solitary-housed WKY (sWKY) rat model with data from previous human studies and validated our results with behavioural studies. As a result, atrophy in sWKY rats was detected in the ventral hippocampus, caudate putamen, lateral septum, cerebellar vermis, and cerebellar nuclei (p < 0.05, corrected for family-wise error rate). Locomotor behaviour was negatively correlated with habenula volume and positively correlated with atrophy of the cerebellar vermis. In addition, sWKY rats showed depletion of sucrose consumption not after reward habituation but without reward habituation. Although the application of sWKY rats in a study of anhedonia might be limited, we observed some similarities between the regions of brain atrophy in sWKY rats and humans with depression, supporting the translation of sWKY rat studies to humans.
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