Evidence map›Paper›PMID 38351090›Full record

ArticleScientific data2024

From MS/MS library implementation to molecular networks: Exploring oxylipin diversity with NEO-MSMS.

Anis Elloumi, Lindsay Mas-Normand, Jamie Bride, Guillaume Reversat, Valérie Bultel-Poncé, Alexandre Guy, Camille Oger, Marie Demion, Jean-Yves Le Guennec, Thierry Durand and 3 more

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Chemical Mechanisms of Lipid Peroxidation.Redox biochemistry and chemistry · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Anis ElloumiInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.ORCID 0000-0002-7794-1138
Lindsay Mas-NormandInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Jamie BridePhyMedExp, Université de Montpellier, Inserm U1046, UMR CNRS 9412, Montpellier, France.
Guillaume ReversatInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Valérie Bultel-PoncéInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Alexandre GuyInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Camille OgerInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Marie DemionPhyMedExp, Université de Montpellier, Inserm U1046, UMR CNRS 9412, Montpellier, France.ORCID 0000-0003-4777-0654
Jean-Yves Le GuennecPhyMedExp, Université de Montpellier, Inserm U1046, UMR CNRS 9412, Montpellier, France.
Thierry DurandInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Claire VigorInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France.
Ángel Sánchez-IllanaInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France. angel.illana@uv.es.ORCID 0000-0001-7630-0614
Jean-Marie GalanoInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS, 34293, Montpellier, France. jean-marie.galano@umontpellier.fr.
Centre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE44-0001Agence Nationale de la Recherche (French National Research Agency) ANR-22-LCV1-0007Generalitat Valenciana (Regional Government of Valencia) CIGE/2022/107
6 · The paper itself

Abstract

Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology and inflammation. Despite their significance, many non-enzymatic oxygenated metabolites of PUFAs (NEO-PUFAs) remain poorly reported, resulting in a lack of public datasets of experimental data and limiting their dereplication in further studies. To overcome this limitation, we constructed a high-resolution tandem mass spectrometry (MS/MS) dataset comprising pure NEO-PUFAs (both commercial and self-synthesized) and in vitro free radical-induced oxidation of diverse PUFAs. By employing molecular networking techniques with this dataset and the existent ones in public repositories, we successfully mapped a wide range of NEO-PUFAs, expanding the strategies for annotating oxylipins, and NEO-PUFAs and offering a novel workflow for profiling these molecules in biological samples.

Indexed as

OxylipinsTandem Mass SpectrometryFatty Acids, UnsaturatedGene LibraryHumansInflammationFatty Acids, UnsaturatedOxylipins

Identifiers

PMID38351090
PMCPMC10864323
OpenAlexW4391781178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.