Evidence map›Paper›PMID 38351082›Full record

ArticleNature communications2024

A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria.

Akbar Espaillat, Laura Alvarez, Gabriel Torrens, Josy Ter Beek, Vega Miguel-Ruano, Oihane Irazoki, Federico Gago, Juan A Hermoso, Ronnie P-A Berntsson, Felipe Cava

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Outer Membrane-Peptidoglycan Anchoring inJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026
    Article
  5. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Bacterial peptidoglycan as a living polymer.Current opinion in chemical biology · 2025
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Akbar Espaillat *Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SciLifeLab, Umeå University, Umeå, Sweden.
Laura Alvarez *Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SciLifeLab, Umeå University, Umeå, Sweden.ORCID 0000-0003-2429-7542
Gabriel Torrens *Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SciLifeLab, Umeå University, Umeå, Sweden.ORCID 0000-0002-0450-1430
Josy Ter BeekDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.ORCID 0000-0003-4165-9277
Vega Miguel-RuanoDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry "Blas Cabrera", CSIC, Madrid, Spain.ORCID 0000-0002-2492-7164
Oihane IrazokiDepartment of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SciLifeLab, Umeå University, Umeå, Sweden.
Federico GagoDepartment of Biomedical Sciences & IQM-CSIC Associate Unit, School of Medicine and Health Sciences, University of Alcalá, E-28805, Madrid, Alcalá de Henares, Spain.ORCID 0000-0002-3071-4878
Juan A HermosoDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry "Blas Cabrera", CSIC, Madrid, Spain.
Ronnie P-A BerntssonDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.ORCID 0000-0001-6848-322X
Felipe CavaDepartment of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, SciLifeLab, Umeå University, Umeå, Sweden. felipe.cava@umu.se.ORCID 0000-0001-5995-718X
Science for Life Laboratory · SEUmeå University · SEUniversidad de Alcalá · ES

Funding

Kempestiftelserna (Kempe Foundations) SMK2062Vetenskapsrådet (Swedish Research Council) 2018-02823Vetenskapsrådet (Swedish Research Council) 2018-05882
6 · The paper itself

Abstract

The bacterial cell-wall peptidoglycan is made of glycan strands crosslinked by short peptide stems. Crosslinks are catalyzed by DD-transpeptidases (4,3-crosslinks) and LD-transpeptidases (3,3-crosslinks). However, recent research on non-model species has revealed novel crosslink types, suggesting the existence of uncharacterized enzymes. Here, we identify an LD-transpeptidase, LDT

Indexed as

Peptidyl TransferasesBacteriaBacterial ProteinsPeptidesPeptidoglycanPolysaccharidesBacterial ProteinsPeptidesPeptidoglycanPeptidyl TransferasesPolysaccharides

Identifiers

PMID38351082
PMCPMC10864386
OpenAlexW4391772683

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.